Structure-activity relationships for human estrogenic activity in zearalenone mycotoxins

Shier WT.; Xie W.; Mirocha CJ.; Shier AC.

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Structure-activity relationships for human estrogenic activity in zearalenone mycotoxins

机译：玉米赤霉烯酮霉菌毒素中人类雌激素活性的构效关系

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Zearalenones are estrogenic Fusarium mycotoxins consisting of a resorcinol moiety fused to a 14-member macrocyclic lactone. Using an improved MCF7 human breast cell proliferation assay, we have compared the estrogenicity of 17 chromatographically-homogeneous zearalenones. Both similarities and substantial differences from published results in intact animal systems were observed. Substantial human estrogenicity was retained even in analogs lacking hydroxylation on the aromatic and macrocyclic rings. (C) 2001 Elsevier Science Ltd. All rights reserved. [References: 29]

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《Toxicon: An International Journal Devoted to the Exchange of Knowledge on the Poisons Derived from Animals, Plants and Microorganisms》 |2001年第9期|共4页
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Shier WT.; Xie W.; Mirocha CJ.; Shier AC.;
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正文语种 eng
中图分类药学;毒物学（毒理学）;
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1. Structure-activity relationships for human estrogenic activity in zearalenone mycotoxins [J] . Shier WT., Xie W., Mirocha CJ., Toxicon: An International Journal Devoted to the Exchange of Knowledge on the Poisons Derived from Animals, Plants and Microorganisms . 2001,第9期

机译：玉米赤霉烯酮霉菌毒素中人类雌激素活性的构效关系
2. In vitro toxicological effects of estrogenic mycotoxins on human placental cells: Structure activity relationships [J] . ProuillacC., KoraichiF., VidemannB., Toxicology and Applied Pharmacology . 2012,第3期

机译：雌激素真菌毒素对人胎盘细胞的体外毒理作用：结构活性关系
3. Estrogenic properties of naturally occurring prenylated isoflavones in U2OS human osteosarcoma cells: Structure-activity relationships. [J] . Djiogue S, Njamen D, Halabalaki M, The Journal of Steroid Biochemistry and Molecular Biology . 2010,第4a5期

机译：U2OS人骨肉瘤细胞中天然存在的烯丙基异黄酮的雌激素特性：结构与活性的关系。
4. Zearalenone: An Estrogenic Mycotoxin with Immunotoxic Effects [C] . I.M. Hueza, V.K. Tanabe, J.C. Benassi, International Symposium on Poisonous Plants . 2011

机译：Zearalenone：具有免疫毒性作用的雌激素霉菌毒素
5. A structure-activity approach to drug action in pharmacology: (A) Structure-activity relationships involved in DT-diaphorase (NQO1) mediated reduction kinetics and mode of action of anticancer bioreductive benzoquinone alkylating agents. (B) Structural characteristics of novel NMDA receptor antagonists required for renal tubule organic cation secretion . [D] . Fourie, Jeanne. 2004

机译：一种在药理学中用于药物作用的结构活性方法：（A）DT-黄递酶（NQO1）介导的抗癌生物还原苯醌烷基化剂的还原动力学和作用方式的结构活性关系。（B）肾小管有机阳离子分泌所需的新型NMDA受体拮抗剂的结构特征。
6. Biotransformation of the Mycotoxin Zearalenone to its Metabolites Hydrolyzed Zearalenone (HZEN) and Decarboxylated Hydrolyzed Zearalenone (DHZEN) Diminishes its Estrogenicity In Vitro and In Vivo [O] . Sebastian Fruhauf, Barbara Novak, Veronika Nagl, 2019

机译：霉菌毒素玉米赤霉烯酮对其代谢产物水解玉米赤霉烯酮（HZEN）和脱羧水解玉米赤霉烯酮（DHZEN）的生物转化降低了其体内和体内的雌激素性。
7. Biotransformation of the Mycotoxin Zearalenone to its Metabolites Hydrolyzed Zearalenone (HZEN) and Decarboxylated Hydrolyzed Zearalenone (DHZEN) Diminishes its Estrogenicity In Vitro and In Vivo [O] . Sebastian Fruhauf, Barbara Novak, Veronika Nagl, 2019

机译：将霉菌毒素的生物转化霉菌与其代谢物水解的Zealalenone（HZEN）和脱羧水解的酸甲酮（DHZEN）在体外和体内减少其雌激素
8. Estrogenic Activity of the Mycotoxins Zearalenone and Zearalanol in the Neonatal Rat Uterus [R] . Sheehan, D. M. , Branham, W. S. , Medlock, K. L. , 1982

机译：霉菌毒素玉米赤霉烯酮和玉米赤霉醇在新生大鼠子宫中的雌激素活性

Structure-activity relationships for human estrogenic activity in zearalenone mycotoxins

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