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首页> 外文期刊>Transplant immunology >Adult stem cell therapy beyond haemopoietic stem cell transplantation? An update.
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Adult stem cell therapy beyond haemopoietic stem cell transplantation? An update.

机译：成人造血干细胞疗法超越造血干细胞移植？更新。

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摘要

The lifesaving potential of haemopoietic stem cell transplantation for the treatment of haematological malignancies and other life threatening disorders of the haemopoietic stem cell is universally accepted. In contrast, the use of adult marrow derived stem cells for tissue repair strategies in degenerative disease or after tissue damage are only in the early stages of evolution. A range of opinion exists within the general public and the scientific community about whether research with human embryonic stem cells is ethically acceptable. Further, the current paucity of human embryonic stem cell data has lead investigators to consider adult marrow as a potential source of stem cells to treat a wide range of degenerative disease and damaged tissues. Target disorders include osteoarthritis, diabetes mellitus, Parkinson's disease, ischaemic heart disease and retinal degeneration. Obvious advantages of this approach, if successful, would be fewer ethical hurdles compared with embryonic stem cells. Treatmentwith the patients own marrow stem cells would eliminate the possibility of allogeneic rejection.
机译：造血干细胞移植在治疗血液系统恶性肿瘤和其他危及生命的造血干细胞疾病中具有挽救生命的潜力。相反，在变性疾病中或在组织损伤后，将成年骨髓来源的干细胞用于组织修复策略只是在进化的早期。对于人类胚胎干细胞的研究在伦理上是否可以接受，在公众和科学界内部存在着各种各样的意见。此外，当前人类胚胎干细胞数据的匮乏，导致研究人员将成年骨髓视为治疗广泛范围的变性疾病和受损组织的干细胞的潜在来源。目标疾病包括骨关节炎，糖尿病，帕金森氏病，缺血性心脏病和视网膜变性。如果成功的话，这种方法的明显优势将是与胚胎干细胞相比更少的伦理障碍。用患者自己的骨髓干细胞进行治疗将消除同种异体排斥的可能性。

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