...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Tumori. >Atypical squamous cells of undetermined significance: analysis of microbiology, cytological criteria and clinical conduct.
【24h】

Atypical squamous cells of undetermined significance: analysis of microbiology, cytological criteria and clinical conduct.

机译：具有重要意义的非典型鳞状细胞：微生物学分析，细胞学标准和临床行为。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

AIMS: To differentiate between two types of atypical squamous cells of undetermined significance (ASCUS): probably neoplastic (PN) or probably reactive (PR), and, in accordance with the recommendations on screening protocols of the Emilia-Romagna Region (PSRER), Italy, to define the best management to follow and the prognosis. Furthermore, the associations between ASCUS and infectious agents and human papillomavirus (HPV) were evaluated. METHODS: Fifty-eight ASCUS smears were reviewed and sorted; if a diagnosis of ASCUS was confirmed, the smear was classified as PR or PN, and the PSRER group was identified. Then, colposcopy was performed with checks for infectious agents (culture evaluation with cytological or clinical criteria) and HPV (hybrid capture). RESULTS: The ASCUS frequency was 3.96%. Of the 58 cases, 33 (56.9%) were diagnosed as ASCUS on review, of which 15 cases were PN and 18 were PR, while 23 (39.7%) smears were normal and 2 (3.4%) showed cervical intraepithelial neoplasia (CIN). There wasa higher frequency of bacterial vaginosis (BV) and HPV in ASCUS PR patients compared with normal cytology, and a higher frequency of CIN in ASCUS PN patients compared with normal controls (P < 0.05). By grouping ASCUS 1 and 3, we observed a higher frequency of CIN and of high-grade colposcopy findings compared with ASCUS 2 and 4 (P < 0.05). From the 23 cases not found to be ASCUS, 18 (87.5%) had normal cytology and colposcopy results on the first follow-up. CONCLUSIONS: Classification of ASCUS as either PN or PR helps in clinical conduct and prognosis, because a higher frequency of CIN is found in ASCUS PN. ASCUS subdivisions, based on PSRER and colposcopy, may facilitate the clinical conduct because ASCUS 1 and 3 with high-grade colposcopic findings proved to be related to the presence of CIN. We propose that initial ASCUS cytology be reviewed, and if it is confirmed, colposcopy should be performed. For those cases found to be normal on review of the cytology results, it is suggested that a cytological check-up be carried out every 6 months.
机译：目的：要区分两种类型的具有不确定性的非典型鳞状细胞（ASCUS）：可能是肿瘤性（PN）或可能是反应性（PR），并且根据关于艾米利亚—罗马涅大区（PSRER）筛查方案的建议，在意大利，要确定要遵循的最佳管理方式和预后。此外，还评估了ASCUS和传染原与人类乳头瘤病毒（HPV）之间的关联。方法：对58例ASCUS涂片进行检查和分类。如果确诊为ASCUS，则将涂片分类为PR或PN，并确定PSRER组。然后，进行阴道镜检查，检查感染因素（根据细胞学或临床标准进行培养评估）和HPV（杂交捕获）。结果：ASCUS频率为3.96％。在58例病例中，经复查诊断为ASCUS的33例（56.9％），其中PN例15例，PR例18例，涂片检查正常的23例（39.7％），宫颈上皮内瘤变（CIN）的2例（3.4％） 。与正常细胞学检查相比，ASCUS PR患者的细菌性阴道病（BV）和HPV发生率更高，与正常对照组相比，ASCUS PN患者的CIN频率更高（P <0.05）。通过将ASCUS 1和3分组，与ASCUS 2和4相比，我们观察到了更高的CIN频率和高级阴道镜检查结果（P <0.05）。在23例未发现ASCUS的病例中，有18例（87.5％）在第一次随访中细胞学和阴道镜检查结果正常。结论：将ASCUS分类为PN或PR有助于临床行为和预后，因为在ASCUS PN中发现CIN的频率更高。基于PSRER和阴道镜的ASCUS细分可能有助于临床操作，因为具有高级阴道镜检查结果的ASCUS 1和3被证明与CIN的存在有关。我们建议对最初的ASCUS细胞学进行检查，如果确诊，应进行阴道镜检查。对于那些在检查细胞学结果后发现正常的病例，建议每6个月进行一次细胞学检查。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号