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首页> 外文期刊>Trends in Microbiology >Anti-inflammatory potential of probiotics: lipoteichoic acid makes a difference
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Anti-inflammatory potential of probiotics: lipoteichoic acid makes a difference

机译:益生菌的抗炎潜力:脂蛋白酸起重要作用

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摘要

Lipoteichoic acid (LTA) mutants of lactobacilli suppress inflammation in animal models of experimental colitis. The fact that a single mutation of an administered Lactobacillus strain can result in enhanced probiotic efficacy is surprising given the genetic diversity and complexity of the intestinal niche, but at the same time exciting from a microbiological, immunological and gastroenterological point of view. In this Opinion article, we discuss the possible impacts of LTA modification in probiotic bacteria in the context of the current knowledge regarding the proinflammatory capacity of LTA, structure-activity relationships of LTA, intestinal LTA recognition in healthy and colitis conditions and anti-inflammatory molecules of lactobacilli.
机译:乳杆菌的脂磷壁酸(LTA)突变体可抑制实验性结肠炎动物模型中的炎症。考虑到肠道小生境的遗传多样性和复杂性,施用的乳酸杆菌菌株的单一突变可导致益生菌功效增强的事实令人惊讶,但同时从微生物学,免疫学和胃肠病学的角度来看也令人兴奋。在这篇观点文章中,我们将在有关LTA的促炎能力,LTA的结构-活性关系,健康和结肠炎条件下肠道LTA的识别以及抗炎分子的最新知识的背景下,讨论LTA修饰对益生菌的可能影响。的乳酸菌。

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