Synthesis and DNA-binding properties of novel DNA cyclo-intercalators containing purine-glucuronic acid hybrids

Zhang Renshuai; Chen Shaopeng; Wang Xueting; Yu Rilei; Li Mingjing; Ren Sumei; Jiang Tao

首页> 外文期刊>Carbohydrate research >Synthesis and DNA-binding properties of novel DNA cyclo-intercalators containing purine-glucuronic acid hybrids

【24h】

Synthesis and DNA-binding properties of novel DNA cyclo-intercalators containing purine-glucuronic acid hybrids

机译：含嘌呤-葡萄糖醛酸杂化物的新型DNA环嵌入剂的合成及DNA结合特性

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Novel DNA cyclo-intercalators, which incorporated two intercalator subunits linked by two bridges, were synthesized. Binding of the compounds to calf-thymus DNA was studied by fluorescence spectroscopy, and docking simulations were used to predict the binding modes of these cyclic compounds. The spectral data demonstrated that all of these compounds can interact with CT-DNA. The sugar moiety played an important role in the process of binding between the intercalators containing glucuronic acid and DNA. The length and flexibility of the connecting bridges affected the binding affinity of the resultant cyclo-intercalators. Docking simulations showed that compounds 7 and 8 interact with DNA as mono-intercalators. (C) 2016 Elsevier Ltd. All rights reserved.

机译：合成了新的DNA环嵌入剂，其中整合了由两个桥连接的两个嵌入剂亚基。通过荧光光谱研究了化合物与小牛胸腺DNA的结合，并使用对接模拟来预测这些环状化合物的结合模式。光谱数据表明所有这些化合物均可与CT-DNA相互作用。糖部分在含葡萄糖醛酸的嵌入剂与DNA之间的结合过程中起着重要作用。连接桥的长度和柔韧性影响所得环嵌入剂的结合亲和力。对接模拟表明，化合物7和8作为单嵌入剂与DNA相互作用。（C）2016 Elsevier Ltd.保留所有权利。

著录项

来源
《Carbohydrate research》 |2016年第null期|共6页
作者
Zhang Renshuai; Chen Shaopeng; Wang Xueting; Yu Rilei; Li Mingjing; Ren Sumei; Jiang Tao;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类有机化学;
关键词
DNA-binding; Cyclo-intercalators; Purine-glucuronic acid;

机译：DNA结合;环嵌入剂;嘌呤-葡萄糖醛酸;

相似文献

外文文献
中文文献
专利

1. Synthesis and DNA-binding properties of novel DNA cyclo-intercalators containing purine-glucuronic acid hybrids [J] . Zhang Renshuai, Chen Shaopeng, Wang Xueting, Carbohydrate research . 2016,第Null期

机译：含嘌呤-葡萄糖醛酸杂化物的新型DNA环嵌入剂的合成及DNA结合特性
2. SYNTHESIS, DNA-BINDING, AND PHOTOCLEAVAGE PROPERTIES OF A SERIOUS OF PORPHYRIN-DAUNOMYCIN HYBRIDS [J] . Zhao Ping, Lu Jia-Zheng, He Juan, Nucleosides, nucleotides and nucleic acids . 2014,第7a9期

机译：卟啉-多柔霉素混合蛋白的合成，DNA结合和光解特性
3. Synthesis, in vitro antiproliferative activity, and DNA-binding properties of hybrid molecules containing pyrrolo(2,1-c)(1, 4)benzodiazepine and minor-groove-binding oligopyrrole carriers. [J] . Baraldi PG, Balboni G, Cacciari B, Journal of Medicinal Chemistry . 1999,第25期

机译：含有吡咯并（2,1-c）（1,4）苯并二氮杂和小沟结合寡吡咯载体的杂合分子的合成，体外抗增殖活性和DNA结合特性。
4. SVM-Based Approach for Predicting DNA-Binding Residues in Proteins from Amino Acid Sequences [C] . International Joint Conference on Bioinformatics, Systems Biology and Intelligent Computing . 2009

机译：基于SVM的方法，用于预测氨基酸序列中的DNA结合残留物
5. THE RESTRICTION ENDONUCLEASE ECO RI: ITS INTRINSIC METAL CENTER AND SPECIFIC INTERACTIONS WITH A DNA RECOGNITION SITE (PROTEIN-NUCLEIC ACID, ZINC METALLOENZYMES, INTERACTIONS CHIRAL METAL COMPLEXES, DNA-BINDING PROTEINS). [D] . PARANAWITHANA, SHANTHI R. 1986

机译：限制性内切酶Eco RI：其内在金属中心以及与DNA识别位点的特定相互作用（蛋白-核酸，锌金属酶，相互作用的手性金属络合物，DNA结合蛋白）。
6. Catalytic and DNA-binding properties of the human Ogg1 DNA N-glycosylase/AP lyase: biochemical exploration of H270 Q315 and F319 three amino acids of the 8-oxoguanine-binding pocket [O] . Patricia Auffret van der Kemp, Jean-Baptiste Charbonnier, Marc Audebert, 2004

机译：人类Ogg1 DNA N-糖基化酶/ AP裂解酶的催化和DNA结合特性：对H270Q315和F319（8-氧代鸟嘌呤结合口袋中的三个氨基酸）的生化探索
7. Structures, spectra, and DNA-binding properties of mixed ligand copper(II) complexes of iminodiacetic acid: The novel role of diimine co-ligands on DNA conformation and hydrolytic and oxidative double strand DNA cleavage [O] . Selvakumar, Balaraman, Rajendiran, Venugopal, Maheswari, Palanisamy Uma, 2009

机译：亚氨基二乙酸混合配体铜（II）配合物的结构，光谱和DNA结合特性：二亚胺共配体对DNA构象以及水解和氧化性双链DNA裂解的新作用
8. Effects of Isoproterenol and Sodium Phenobarbital on DNA (Deoxyribonucleic Acids) Replication, Nuclear Protein Synthesis and Cell Ultrastructure in the (C3HxVY) F1 Hybrid Mouse [R] . Pipkin, J. L. 1984

机译：异丙肾上腺素和苯巴比妥钠对（C3HxVY）F1杂种小鼠DNa（脱氧核糖核酸）复制，核蛋白合成及细胞超微结构的影响

Synthesis and DNA-binding properties of novel DNA cyclo-intercalators containing purine-glucuronic acid hybrids

摘要

著录项

相似文献

相关主题

期刊订阅