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首页> 外文期刊>Chinese science bulletin >Three-dimensional reconstruction and analysis of structure characteristics on senile plaques of Alzheimer's disease
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Three-dimensional reconstruction and analysis of structure characteristics on senile plaques of Alzheimer's disease

机译：阿尔茨海默氏病老年斑的三维重建和结构特征分析

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摘要

Alzheimer's disease is a progressive neuro-degenerative disorder characterized by the presence of senile plaques primarily composed of amyloid beta in brain. Abnormal secretion and aggregation of amyloid beta are the key events in pathogenesis of Alzheimer's disease. Reduction of amyloid beta production and inhibition of amyloid beta aggregation to form senile plaques are hopeful strategies for the treatment and prevention of Alzheimer's disease. In the present study, the silver and immunohistochemical staining methods were applied to discover senile plaques in the hippocampus of Alzheimer's disease patients, and then images were processed and three-dimensionally reconstructed by Matlab and AVS software. The structure characteristics of senile plaques were measured through correlation function calculation and fractal dimension by a computer-aided method. Diffuse plaque had no amyloid center, but classic plaque presented compact central core structure; two types of plaques were both of porous structure, but the sizes of their pores were significantly different. Furthermore, there was difference in fractal dimension value between the diffuse plaque and classic plaque in the two staining methods. The comparison of structure characteristics between two types of plaques indicated that they developed independently. Establishment of the methods for reconstructing the three-dimensional structure of senile plaque and analyzing their structure characteristics is helpful for further study on the aggregation mechanism of senile plaque.
机译：阿尔茨海默氏病是一种进行性神经退行性疾病，其特征在于脑中存在主要由淀粉样蛋白β组成的老年斑。淀粉样β蛋白的异常分泌和聚集是阿尔茨海默氏病发病机理中的关键事件。减少淀粉样蛋白β的产生和抑制淀粉样蛋白β聚集以形成老年斑是治疗和预防阿尔茨海默氏病的有希望的策略。在本研究中，银和免疫组织化学方法被用于发现阿尔茨海默氏病患者海马中的老年斑，然后通过Matlab和AVS软件对图像进行处理和三维重建。通过计算机辅助方法，通过相关函数计算和分形维数来测量老年斑的结构特征。弥散性斑块没有淀粉样蛋白中心，但经典斑块具有紧凑的中心核心结构。两种噬菌斑均具有多孔结构，但它们的孔大小明显不同。此外，在两种染色方法中，弥散斑和经典斑之间的分形维数值存在差异。两种噬菌斑之间的结构特征比较表明，它们是独立发育的。建立用于重建老年斑三维结构并分析其结构特征的方法，有助于进一步研究老年斑的聚集机理。

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