The design, synthesis, conformation and bioactivity of deltorphins analogues

WANG Rui; HU Xiaoyu; JIA Qing; JI Hong; WANG Qin

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The design, synthesis, conformation and bioactivity of deltorphins analogues

机译：deltorphins类似物的设计，合成，构象和生物活性

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Deltorphins are endogenous linear heptapeptides, isolated from skin extracts of frogs (genus phyllomedusa) in 1989, which have a higher affinity and selectivity for 8 opioid binding sites than any other known natural compound. The analgesic activity,immunological competence of deltorphins and the conformation of deltorphin II have never been reported previously. Here we report some new phenomena on the structure and bioactivity relationship of deltorphins analogues.

机译：Deltorphins是一种内源性线性七肽，于1989年从蛙类（phyllomedusa属）的皮肤提取物中分离出，对8个阿片样物质结合位点的亲和力和选择性高于任何其他已知的天然化合物。以前尚未报道过deltorphin的镇痛活性，免疫能力和deltorphin II的构象。在这里，我们报告了有关deltorphins类似物的结构和生物活性关系的一些新现象。

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来源
《Chinese science bulletin》 |1995年第16期|共5页
作者
WANG Rui; HU Xiaoyu; JIA Qing; JI Hong; WANG Qin;
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正文语种 eng
中图分类自然科学现状及发展;
关键词
deltorphins; solid phase peptide synthesis; 2D-N1Y1R; red cell immunological competence; analgesia;

机译：地啡肽;固相肽合成;2D-N1Y1R;红细胞免疫能力;镇痛;

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专利

1. The design, synthesis, conformation and bioactivity of deltorphins analogues [J] . WANG Rui, HU Xiaoyu, JIA Qing, Chinese science bulletin . 1995,第16期

机译：deltorphins类似物的设计，合成，构象和生物活性
2. [D-Ala(2)]-deltorphin I peptoid and retropeptoid analogues: Synthesis, biological activity and conformational investigations [J] . Biondi L, Giannini E, Filira F, Journal of peptide science: An official publication of the European Peptide Society . 2004,第9期

机译：[D-Ala（2）]-deltorphin I类肽和类后肽类似物：合成，生物学活性和构象研究
3. Conformationally restricted analogues of psorospermin: Design, synthesis, and bioactivity of natural-product-related bisfuranoxanthones [J] . Heald RA, Dexheimer TS, Vankayalapati H, Journal of Medicinal Chemistry . 2005,第8期

机译：Psorospermin的构象受限类似物：天然产物相关的双呋喃黄嘌呤的设计，合成和生物活性
4. Highly selective cyclic peptides for human melanocortin-4 receptor (MC-4):design,synthesis,bioactive conformation,and pharmacological evaluation as an anti-obesity agent [C] . Waleed Danho, Joseph Swistok, Adrian Cheung, the International Peptide Symposium . 2001

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5. Isolation and structure determination of bioactive natural products from Physena madagascariensis and the design and synthesis of 24-nortriterpene analogues. [D] . Deng, Yonghong. 2001

机译：马达加斯加Phys（Physena madagascariensis）生物活性天然产物的分离和结构测定，以及24-降三萜类似物的设计和合成。
6. Physicochemical analyses of a bioactive 4-aminoantipyrine analogue - synthesis crystal structure solid state interactions antibacterial conformational and docking studies [O] . Mohammad Sayed Alam, Dong-Ung Lee 2016

机译：生物活性4-氨基安替比林类似物的理化分析-合成晶体结构固态相互作用抗菌构象和对接研究
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The design, synthesis, conformation and bioactivity of deltorphins analogues

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