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首页> 外文期刊>Hematology. >Iron deficiency anaemia and evaluation of the utility of iron deficiency indicators among healthy Nigerian children.
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Iron deficiency anaemia and evaluation of the utility of iron deficiency indicators among healthy Nigerian children.

机译：尼日利亚健康儿童中的缺铁性贫血和缺铁性指标的实用性评估。

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The hemoglobin (Hb), serum iron (SI), total iron binding capacity (TIBC), transferrin saturation (TS) and serum ferritin (SF) values of 240 apparently healthy children were determined in a prospective cross-sectional study conducted in Port Harcourt, Nigeria. Standard colorimetric and enzyme immunoassay procedures were used for the estimation all variables. The mean values of all parameters in this study population were; Hb (11.2 +/- 1.83 gldl), TIBC (361.4 +/- 245.7 ugldl, log(c) SI (1.807 +/- 0.45), log(c) SF (1.51 +/- 0.47) and TS (29.3 +/- 18.5%). There was an age-dependent statistical significant difference in the Hb, TIBC and TS values (P < 0.01). Sex was not found to exert any significant influence on the parameters except TIBC. TS had the highest sensitivity and efficiency values of 48 and 95%, respectively. Positive predictive value (PPV), likelihood ratio (LR(+)) and post-test probability values were highest with SF (58%, 3.3 and 62.2%, respectively) as a diagnostic indicator. Hb values correlated positively and significantly with TS (P < 0.01), log(c) SI and log(c) SF concentrations (P < 0.05). Log(c) SF also correlated positively and significantly with Hb and TIBC (P < 0.05). The overall prevalence of iron deficiency anaemia among these children was 33.75%. We conclude that there is a high prevalence of iron deficiency anaemia among apparently healthy children under the age of five years in this part of the world and these results may justify the need for the introduction of a broad intervention programme for this highly vulnerable group. This study is also in support of the hypothesis that SF is the best test for diagnosing or excluding iron deficiency anaemia. The combination of SF, Hb and TS determinations may prove more useful in a resource-limited moderate setting.
机译：在Port Harcourt进行的一项前瞻性横断面研究中确定了240名显然健康的儿童的血红蛋白（Hb），血清铁（SI），总铁结合能力（TIBC），转铁蛋白饱和度（TS）和血清铁蛋白（SF）值，尼日利亚。使用标准的比色法和酶免疫法对所有变量进行估算。该研究人群中所有参数的平均值为： Hb（11.2 +/- 1.83 gldl），TIBC（361.4 +/- 245.7 ugldl，log（c）SI（1.807 +/- 0.45），log（c）SF（1.51 +/- 0.47）和TS（29.3 + / -18.5％）。Hb，TIBC和TS值存在年龄相关的统计学显着性差异（P <0.01）。除TIBC外，未发现性别对参数有显着影响，TS的敏感性和效率最高。 SF的阳性预测值（PPV），似然比（LR（+））和测试后的概率值最高，分别以SF（分别为58％，3.3和62.2％）作为诊断指标。 Hb值与TS（P <0.01），log（c）SI和log（c）SF浓度呈显着正相关（P <0.05）。Log（c）SF与Hb和TIBC也呈显着正相关（P <0.05） ）。这些儿童的缺铁性贫血总患病率为33.75％，我们得出结论，在五岁以下的显然健康的儿童中，缺铁性贫血的患病率很高。在世界这部分地区，这些结果可能证明有必要为这个高度脆弱的人群引入广泛的干预计划。这项研究也支持以下假设：SF是诊断或排除铁缺乏性贫血的最佳方法。 SF，Hb和TS确定的组合在资源有限的适度设置中可能更有用。

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