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What is the relationship between epidermal growth factor-like domain 7 and RhoC in metastasis of hepatocellular carcinoma?

机译:表皮生长因子样结构域7与RhoC在肝细胞癌转移中的关系是什么?

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摘要

We read with great interest the article written by Yang et al.1 in which they showed for the first time that epidermal growth factor-like domain 7 (Egfl7) promotes metastasis of hepatocellular carcinoma (HCC) by enhancing cell motility through epidermal growth factor receptor (EGFR)-dependent focal adhesion kinase (FAK) phosphorylation. They suggested Egfl7 as a novel prognostic marker for metastasis of HCC and a potential therapeutic target. Very interestingly, the same group demonstrated in previous work that RhoC also plays a critical role in metastasis of HCC, which is consistent with our result of RhoC in gastric cancer.
机译:我们非常感兴趣地阅读了Yang等人1的文章,其中他们首次表明表皮生长因子样结构域7(Egf1)通过通过表皮生长因子受体增强细胞运动来促进肝细胞癌(HCC)的转移。 (EGFR)依赖性粘着斑激酶(FAK)磷酸化。他们建议将Egf17作为HCC转移的新预后标志物和潜在的治疗靶标。非常有趣的是,同一小组在以前的研究中证明RhoC在肝癌转移中也起着关键作用,这与我们在胃癌中RhoC的结果一致。

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