Prospective human trials with Dengue virus vaccines and NS1 antigen production among vaccine recipients

AryaS.C.; AgarwalN.

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Prospective human trials with Dengue virus vaccines and NS1 antigen production among vaccine recipients

机译：登革热病毒疫苗和疫苗接种对象中NS1抗原产生的前瞻性人体试验

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There has been phenomenal progress coward development of effective vaccines against dengue virus employing live attenuated vaccines, recombinant virus vectors, recombinant proteins and DNA vaccines. Irrespective of the technology employed for candidate vaccine lots, their genetic stability, phenotypic stability, and immunogenicity including viremia would have to be excellent. Consequently, with every phase I, II and III clinical trial, safety, humoral immunity, cellular immune responses including cytokine profile, CD8/Th bias, serotype dominance, recombination, and reversion to virulence including any transmission to vectors should be scrutinized meticulously.

机译：使用减毒活疫苗，重组病毒载体，重组蛋白和DNA疫苗的抗登革热病毒有效疫苗的开发取得了惊人的进展。无论候选疫苗批次采用何种技术，它们的遗传稳定性，表型稳定性以及包括病毒血症在内的免疫原性都必须非常出色。因此，在每一个I，II和III期临床试验中，都应仔细检查安全性，体液免疫，细胞免疫应答（包括细胞因子谱，CD8 / Th偏倚，血清型优势，重组和回复毒力，包括向载体的任何传播）。

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《Human vaccines》 |2011年第12期|共1页
作者
AryaS.C.; AgarwalN.;
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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
Dengue; Human trials; NS1 antigen production; Vaccines;

机译：登革热;人类试验;NS1抗原产生;疫苗;

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1. Prospective human trials with Dengue virus vaccines and NS1 antigen production among vaccine recipients [J] . AryaS.C., AgarwalN. Human vaccines . 2011,第12期

机译：登革热病毒疫苗和疫苗接种对象中NS1抗原产生的前瞻性人体试验
2. Different Innate Signatures Induced in Human Monocyte-derived Dendritic Cells by Wild-Type Dengue 3 Virus, Attenuated but Reactogenic Dengue 3 Vaccine Virus, or Attenuated Nonreactogenic Dengue 1–4 Vaccine Virus Strains [J] . Claire Balas, Audrey Kennel, Florence Deauvieau, Journal of Infectious Diseases . 2011,第1期

机译：野生型登革3病毒，减毒但有反应性的登革3疫苗病毒或减毒的非反应性登革1–4疫苗病毒株在人单核细胞衍生的树突状细胞中诱导的不同先天特征。
3. Adenovirus-based vaccines generate cytotoxic T lymphocytes to epitopes of NS1 from dengue virus that are present in all major serotypes. [J] . Gao G, Wang Q, Dai Z, Human gene therapy . 2008,第9期

机译：基于腺病毒的疫苗从所有主要血清型中都存在的登革热病毒产生针对NS1表位的细胞毒性T淋巴细胞。
4. Synthesis and refolding of G20,a potential antigen for human Respiratory Syncytial Virus (hRSV) vaccine [C] . Christine Klinguer-Hamour, Marie-Claire Bussat, Helene Plotnicky-Gilquin, European Peptide Symposium . 2002

机译：G20的合成和重折叠，人类呼吸合胞病毒（HRSV）疫苗的潜在抗原
5. Development of improved dengue 2 antigen configurations for a Venezuelan equine encephalitis virus replicon particle-launched dengue vaccine [D] . Webb, Drue Laine 2008

机译：委内瑞拉马脑炎病毒复制子颗粒登革热疫苗的改进登革2抗原构型的开发
6. Dengue virus-specific human CD4+ T-lymphocyte responses in a recipient of an experimental live-attenuated dengue virus type 1 vaccine: bulk culture proliferation clonal analysis and precursor frequency determination. [O] . S Green, I Kurane, R Edelman, 1993

机译：实验性减毒的1型登革热减毒活疫苗中的登革热病毒特异性人CD4 + T淋巴细胞反应：整体培养增殖克隆分析和前体频率测定。
7. Dengue virus-specific human CD4+ T-lymphocyte responses in a recipient of an experimental live-attenuated dengue virus type 1 vaccine: bulk culture proliferation, clonal analysis, and precursor frequency determination [O] . S Green, I Kurane, R Edelman, 1993

机译：特异性病毒特异性人CD4 + T淋巴细胞反应在实验活病毒病毒类型1疫苗：散装培养增殖，克隆分析和前体频率测定

Prospective human trials with Dengue virus vaccines and NS1 antigen production among vaccine recipients

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