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Multiple Subtypes of Serotonin Receptors in the Feeding Circuit of a Pond Snail

机译：池塘蜗牛饲养回路中5-羟色胺受体的多种亚型

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摘要

In the central nervous system of the pond snail Lymnaea stagnalis, serotonergic transmission plays an important role in controlling feeding behavior. Recent electrophysiological studies have claimed that only metabotropic serotonin (5-HT2) receptors, and not ionotropic (5-HT3) receptors, are used in synapses between serotonergic neurons (the cerebral giant cells, CGCs) and the follower buccal motoneurons (the B1 cells). However, these data are inconsistent with previous results. In the present study, we therefore reexamined the serotonin receptors to identify the receptor subtypes functioning in the synapses between the CGCs and the B1 cells by recording the compound excitatory postsynaptic potential (EPSP) of the B1 cells evoked by a train of stimulation to the CGC in the presence of antagonists: cinanserin for 5-HT2 and/or MDL72222 for 5-HT3. The compound EPSP amplitude was partially suppressed by the application of these antagonists. The rise time of the compound EPSP was longer in the presence of MDL72222 than in that of cinanserin. These results suggest that these two subtypes of serotonin receptors are involved in the CGC-B1 synapses, and that these receptors contribute to compound EPSP. That is, the fast component of compound EPSP is mediated by 5-HT3-like receptors, and the slow component is generated via 5-HT2-like receptors.
机译：在池塘蜗牛的中枢茎线虫中枢神经系统中，血清素能传递在控制摄食行为中起着重要作用。最近的电生理研究声称，在血清素能神经元（大脑巨细胞，CGC）和后继颊运动神经元（B1细胞）之间的突触中仅使用了代谢型5-羟色胺（5-HT2）受​​体，而没有离子型（5-HT3）受体。 ）。但是，这些数据与先前的结果不一致。因此，在本研究中，我们通过记录一系列刺激CGC所诱发的B1细胞的复合兴奋性突触后电位（EPSP），从而重新检查了血清素受体，以识别CGC与B1细胞突触中起作用的受体亚型。在存在拮抗剂的情况下：肉桂醛对5-HT2和/或MDL72222对5-HT3。通过使用这些拮抗剂，化合物EPSP幅度被部分抑制。在MDL72222存在下，化合物EPSP的上升时间比在肉桂酸甘油酯中的上升时间更长。这些结果表明，血清素受体的这两个亚型参与了CGC-B1突触，并且这些受体有助于化合物EPSP。即，化合物EPSP的快速组分由5-HT3样受体介导，而慢组分通过5-HT2样受体产生。

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