Evaluating the vaccine potential of an influenza A viral hemagglutinin and matrix double insertion DNA plasmid.

Xie H; Liu T; Chen H; Huang X; Ye Z

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Evaluating the vaccine potential of an influenza A viral hemagglutinin and matrix double insertion DNA plasmid.

机译：评估甲型流感病毒血凝素和基质双插入DNA质粒的疫苗潜力。

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A DNA plasmid expressing both the influenza viral matrix protein (M1) and hemagglutinin (HA) (pHA/M1) as a potential vaccine candidate was investigated. Vaccination with pHA/M1 double insertion plasmids not only induced HA-specific protective antibodies, but also elicited HA and M1-specific CD8 T cell responses. Mice immunized with pHA/M1 dual expressing plasmid showed enhanced HA inhibition titer and increased CD69(+) CD8alpha(+) T cell response compared to groups that received either the vector or a mixture of both pHA and pM1 (pHA+pM1). Furthermore, pHA/M1 immunization resulted in improved protection against both homologous and heterologous challenges.

机译：研究了同时表达流感病毒基质蛋白（M1）和血凝素（HA）（pHA / M1）作为潜在候选疫苗的DNA质粒。用pHA / M1双插入质粒接种疫苗不仅诱导HA特异性保护性抗体，而且还引起HA和M1特异性CD8 T细胞应答。与接受载体或pHA和pM1（pHA + pM1）混合物的组相比，用pHA / M1双表达质粒免疫的小鼠显示出更高的HA抑制效价和增加的CD69（+）CD8alpha（+）T细胞应答。此外，pHA / M1免疫可提高抵抗同源和异源攻击的保护能力。

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《Vaccine》 |2007年第44期|共7页
作者
Xie H; Liu T; Chen H; Huang X; Ye Z;
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正文语种 eng
中图分类卫生标准、卫生检查、医药管理;
关键词
Sjogren's syndrome B antibody; Plasmids; Vaccines; Influenza; Hemagglutinins; 质粒; 疫苗; 流感; 血凝素类;

机译：Sjogren's syndrome B antibody;Plasmids;Vaccines;Influenza;Hemagglutinins;质粒;疫苗;流感;血凝素类;

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1. Evaluating the vaccine potential of an influenza A viral hemagglutinin and matrix double insertion DNA plasmid. [J] . Xie H, Liu T, Chen H, Vaccine . 2007,第44期

机译：评估甲型流感病毒血凝素和基质双插入DNA质粒的疫苗潜力。
2. Phase I clinical evaluation of seasonal influenza hemagglutinin (HA) DNA vaccine prime followed by trivalent influenza inactivated vaccine (IIV3) boost [J] . Ledgerwood Julie E., Hu Zonghui, Costner Pamela, Contemporary clinical trials . 2015,第Null期

机译：季节性流感血凝素（HA）DNA疫苗初次接种三价流感灭活疫苗（IIV3）的I期临床评估
3. DNA-based influenza vaccines: evaluating their potential to provide universal protection. [J] . Choo AY, Broderick KE, Kim JJ, IDrugs: the investigational drugs journal . 2010,第10期

机译：基于DNA的流感疫苗：评估其提供普遍保护的潜力。
4. Towards Cell Culture-Based Influenza Vaccine Design: Impact of Viral Hemagglutinin N-Glycosylation on Immunogenicity [C] . Hutter J., Rodig J., Hoper D. International Carbohydrate Symposium . 2013

机译：致细胞培养的流感疫苗设计：病毒血凝素N-糖基化对免疫原性的影响
5. Protective Potential of H1N1 Influenza Hemagglutinin Stalk Domain Antibodies: Implications for a Universal Influenza Vaccine [D] . Christensen, Shannon Renee. 2020

机译：H1N1流感血凝素茎域抗体的保护潜力：对普遍流感疫苗的影响
6. Phase I clinical evaluation of seasonal influenza hemagglutinin (HA) DNA vaccine prime followed by trivalent influenza inactivated vaccine (IIV3) boost [O] . Julie E. Ledgerwood, Zonghui Hu, Pamela Costner, -1

机译：季节性流感血凝素（HA）DNA疫苗初次接种三价流感灭活疫苗（IIV3）的I期临床评估
7. Phase I clinical evaluation of seasonal influenza hemagglutinin (HA) DNA vaccine prime followed by trivalent influenza inactivated vaccine (IIV3) boost [O] . Julie E. Ledgerwood, Zonghui Hu, Pamela Costner, 2015

机译：I阶段I季节性流感血凝素（HA）DNA疫苗素的临床评价，然后是三价流感灭活疫苗（IIV3）提升

Evaluating the vaccine potential of an influenza A viral hemagglutinin and matrix double insertion DNA plasmid.

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