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首页> 外文期刊>Vaccine >Cloning, expression and evaluation of the efficacy of a recombinant Baylisascaris schroederi Bs-Ag3 antigen in mice
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Cloning, expression and evaluation of the efficacy of a recombinant Baylisascaris schroederi Bs-Ag3 antigen in mice

机译：重组Baylisascaris schroederi Bs-Ag3抗原在小鼠中的克隆，表达及功效评估

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摘要

The gene Bs-Ag3 enconding a antigen of 37 kDa from Baylisascaris schroederi (giant panda isolates), as well as the recombinant Bs-Ag3, obtained by cloning and expression of the Bs-Ag3 gene in heterologous host Escherichia coli BL-21 (DE3), were used to evaluate their ability to induce immune protective responses in BALB/c mice against L3-challenge infection in a mouse-B. schroederi model. There was a significant reduction (62.91%) of mice vaccinated with rBs-Ag3 coupled with Freund's complete adjuvant (FCA) in recovery of challenged B. schroederi L3 compared with either controls or mice vaccinated with FCA alone. Our data indicate recombinant Bs-Ag3 may be a potential target as a vaccine antigen for giant panda ascariasis.
机译：通过克隆和在异源宿主大肠杆菌BL-21（DE3）中表达Bs-Ag3基因获得的重组Bs-Ag3基因，该基因包含来自Baylisascaris schroederi（巨型熊猫分离株）的37 kDa抗原。 ），用于评估它们在BALB / c小鼠中诱导针对B型小鼠L3挑战感染的免疫保护反应的能力。 schroederi模型。与单独接种FCA的对照组或小鼠相比，接种rBs-Ag3结合弗氏完全佐剂（FCA）的小鼠在受攻击的schroederi L3的回收率上有显着降低（62.91％）。我们的数据表明重组Bs-Ag3作为大熊猫as虫病的疫苗抗原可能是潜在的靶标。

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