Persistence of immunologic memory for 13 years in recipients of a recombinant hepatitis B vaccine

Watson B; West DJ; Chilkatowsky A; Piercy S; Ioli VA

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Persistence of immunologic memory for 13 years in recipients of a recombinant hepatitis B vaccine

机译：重组乙型肝炎疫苗接种者的免疫记忆持续存在13年

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All subjects in this clinical study gave informed written consent, and guidelines of the authors' institution regarding human experimentation were observed in the conduct of the study. A booster dose of vaccine given to 18 adolescents (immunized as children) and 7 older adults immunized 13 years earlier with a 3-dose course of recombinant hepatitis B vaccine induced a strong secondary antibody response, demonstrating that the vaccinees retained immunologic memory for HbsAG. Within one week. booster vaccination induced an 11 to 24-fold rise in the GMT of anti-HBs which continued. reaching 52 to 319-fold after 4 weeks. Significantly even the 5 individuals with less than 10 mIU/ml of anti-HBs prior to the booster all had impressive responses to the booster dose.

机译：该临床研究中的所有受试者均给予知情的书面同意，并且在研究过程中遵守了作者机构关于人体实验的指导原则。对18例青少年（儿童免疫）和7例13年前进行了3剂量疗程的重组乙型肝炎疫苗免疫的老年人，增加了剂量的疫苗诱导了强烈的二抗反应，表明这些疫苗保留了HbsAG的免疫记忆。一星期之内。加强疫苗接种后，抗-HBs的GMT升高了11到24倍，并持续上升。 4周后达到52到319倍。值得注意的是，即使在加强免疫前抗HBs低于10 mIU / ml的5个人对加强剂量也有令人印象深刻的反应。

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来源
《Vaccine》 |2001年第24期|共5页
作者
Watson B; West DJ; Chilkatowsky A; Piercy S; Ioli VA;
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正文语种 eng
中图分类卫生标准、卫生检查、医药管理;
关键词
Recombinant hepatitis b vaccine; Persistance of immunity; Responses; Children;

机译：重组乙型肝炎疫苗;免疫力持久;反应;儿童;

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1. Persistence of immunologic memory for 13 years in recipients of a recombinant hepatitis B vaccine [J] . Watson B, West DJ, Chilkatowsky A, Vaccine . 2001,第23a24期

机译：重组乙型肝炎疫苗接种者的免疫记忆持续存在13年
2. Intradermal Vaccination of Adults with Three Low Doses (2 μg) of Recombinant Hepatitis B Vaccine. II. Persistence of Immunity and Induction of Immunologic Memory [J] . Maria do Carmo M Elisb?o, JoséLuís da S Baldy, Ana Maria Bonametti, Memorias do Instituto Oswaldo Cruz . 2003,第8期

机译：成年人的三种低剂量（2μg）重组乙型肝炎疫苗的皮内疫苗接种。二。免疫力的持久性和免疫记忆的诱导
3. Persistence of protection against hepatitis B virus infection among adolescents vaccinated with recombinant hepatitis B vaccine beginning at birth: a 15-year follow-up study. [J] . Bialek SR, Bower WA, Novak R, The Pediatric infectious disease journal . 2008,第10期

机译：一项从出生开始就接种重组乙型肝炎疫苗的青少年中对乙型肝炎病毒感染的持久保护作用：一项为期15年的随访研究。
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机译：M13噬菌体疫苗的免疫基础：在阿尔茨海默病的小鼠模型中测试了有效的疫苗设计
5. Edible vaccines: Immunological response to hepatitis B virus nucleocapsid derived from transgenic plants. [D] . Falzarano, Darryl Lee. 2005

机译：食用疫苗：对源自转基因植物的乙型肝炎病毒核衣壳的免疫反应。
6. The persistence of anti-HBs antibody and anamnestic response 20 years after primary vaccination with recombinant hepatitis B vaccine at infancy [O] . Masoomeh Bagheri-Jamebozorgi, Jila Keshavarz, Maryam Nemati, 2014

机译：婴儿初次接种重组乙型肝炎疫苗后20年抗HBs抗体的持久性和记忆消除反应
7. Intradermal vaccination of adults with three low doses (2 µg) of recombinant hepatitis B vaccine. II. Persistence of immunity and induction of immunologic memory [O] . Maria do Carmo M Elisbão, José Luís da S Baldy, Ana Maria Bonametti, 2003

机译：用三种低剂量（2μg）重组乙型肝炎疫苗对成人进行皮内接种。 II。持续免疫和诱导免疫记忆
8. Dengue-2 Vaccine: Virological, Immunological, and Clinical Responses of Six Yellow Fever-Immune Recipients [R] . Bancroft, W. H., Top, F. H., Eckels, K. H., 1980

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Persistence of immunologic memory for 13 years in recipients of a recombinant hepatitis B vaccine

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