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首页> 外文期刊>Vaccine >Comparison of measles virus-specific antibody titres as measured by enzyme-linked immunosorbent assay and virus neutralisation assay
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Comparison of measles virus-specific antibody titres as measured by enzyme-linked immunosorbent assay and virus neutralisation assay

机译：酶联免疫吸附法和病毒中和法测定的麻疹病毒特异性抗体滴度的比较

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摘要

We assessed whether measles virus-specific antibody levels in the Dutch population as estimated by an enzyme-linked immunosorbent assay (ELISA) were comparable with estimates by virus neutralisation assay (NT), prompted by a relatively low ELISA seroprevalence in the 10-21-year-old group. We tested 791 sera from individuals aged 2-49 years both in ELISA and NT. Seroprevalence in the 10-21-year-old group was 93.4% (95% confidence interval (CI) 89.5-97.2%) in ELISA versus 97.2% (CI 94.7-99.6%) in NT. There was good agreement between NT and ELISA seroprevalences in the vaccinated 2-9-year-olds and the unvaccinated 22-49-year-olds.
机译：我们评估了通过酶联免疫吸附测定（ELISA）估算的荷兰人群中麻疹病毒特异性抗体水平是否与通过病毒中和测定（NT）估算的结果相媲美，这是由于10-21-岁的组。我们在ELISA和NT中测试了2-49岁年龄段的791位血清。 10-21岁组的血清阳性率在ELISA中为93.4％（95％置信区间（CI）89.5-97.2％），而在NT中为97.2％（CI 94.7-99.6％）。在接种疫苗的2-9岁儿童和未接种疫苗的22-49岁儿童中，NT和ELISA血清阳性率之间存在良好的一致性。

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