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首页> 外文期刊>Vaccine >Comparison of PorA VR types and porA promoter sequence from Neisseria meningitidis B isolated from non-immunised children and vaccine failures immunised with a serogroup B outer membrane protein vaccine
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Comparison of PorA VR types and porA promoter sequence from Neisseria meningitidis B isolated from non-immunised children and vaccine failures immunised with a serogroup B outer membrane protein vaccine

机译：从未免疫儿童分离的脑膜炎奈瑟氏菌B的PorA VR类型和porA启动子序列的比较以及用血清群B外膜蛋白疫苗免疫的疫苗失败

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摘要

PorA protein is an important component of group B meningococcal protein-based vaccines. The goals of this study were: (i) to classify the non-serosubtypable strains recovered from vaccine failures and controls by porA variable region (VR) type; (ii) to investigate if point mutations of VRs of the porA gene are present in P1.19,15 strains recovered from vaccine failures and controls; (iii) to investigate if nucleotide sequence variation in the promoter region of porA gene is related to low expression of PorA protein. VR type P1.19,15 predominated in younger vaccine failures (3-47 months) compared to older failures (48-83 months). No changes in VRs of porA were observed in 46 P1.19,15 strains studied. A promoter spacer of 16 bp and 10 guanidine residues in the polymeric G tract was detected in five of six strains with weak PorA expression. Overall, this study indicated that lack of antibody response was probably the major cause of low vaccine efficacy in young children.
机译：PorA蛋白是B组基于脑膜炎球菌蛋白的疫苗的重要组成部分。这项研究的目标是：（i）按porA可变区（VR）类型对从疫苗失败和对照中回收的非血清亚型菌株进行分类; （ii）调查从疫苗失效和对照中回收的P1.19,15菌株中是否存在porA基因VR的点突变; （iii）研究porA基因启动子区域的核苷酸序列变化是否与PorA蛋白的低表达有关。与较早的疫苗接种失败（48-83个月）相比，较年轻的疫苗接种失败（3-47个月）主要是VR型P1.19,15。在研究的46个P1.19,15菌株中未观察到porA VR的变化。在六个具有弱PorA表达的菌株中的五个菌株中，在聚合物G道中检测到一个具有16 bp和10个胍残基的启动子间隔区。总体而言，这项研究表明抗体反应不足可能是导致幼儿疫苗效力低下的主要原因。

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