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When the blood glucose and the HbA1c don't match: Turning uncertainty into opportunity

机译:当血糖和HbA1c不匹配时:将不确定性转化为机会

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摘要

Acentral principle in science and medicine is that the more independent pieces of evidence there are that agree, the more convincing it is that a hypothesis-or diagnosis-is valid. The opposite is also true: discordant information leads to uncertainty. Unfortunately, it is not uncommon for clinicians caring for people with diabetes to encounter individuals in whom HbA_(1c) and blood glucose simply do not match. Sometimes, there is an obvious explanation such as hemolytic anemia. But when it occurs in people with reliable blood glucose records and ostensibly normal peripheral blood and reticulocyte counts, without evidence of hemoglobinopathy, hemolytic disorder, blood loss/transfusion, or nutritional deficiency such as iron, folate, or vitamin B12, we are left with the questions of how the discordant information should be treated and what it means for patient care.
机译:科学和医学的中心原则是,达成共识的证据越独立,就越有说服力的假设或诊断是有效的。反之亦然:信息不一致会导致不确定性。不幸的是,照顾糖尿病患者的临床医生遇见HbA_(1c)和血糖根本不匹配的个体并不少见。有时,会有明显的解释,例如溶血性贫血。但是,如果发生在血糖记录可靠且外周血和网织红细胞计数正常的人中,而又没有血红蛋白病,溶血病,失血/输血或营养不足(例如铁,叶酸或维生素B12)的证据,有关如何处理不一致信息以及对患者护理意味着什么的问题。

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