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Two cell lineages, myf5 and myf5-independent, participate in mouse skeletal myogenesis

机译：myf5和myf5独立的两个细胞谱系参与小鼠骨骼肌的发生

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In skeletal muscle development, the myogenic regulatory factors myf5 and myoD play redundant roles in the specification and maintenance of myoblasts, whereas myf6 has a downstream role in differentiating myocytes and myofibers. It is not clear whether the redundancy between myf5 and rnyoD is within the same cell lineage or between distinct lineages. Using lineage tracing and conditional cell ablation in mice, we demonstrate the existence of two distinct lineages in myogenesis: a myf5 lineage and a myf5-independent lineage. Ablating the myf5 lineage is compatible with myogenesis sustained by myf5-independent, myoD-expressing myoblasts, whereas ablation of the myf6 lineage leads to an absence of all differentiated myofibers, although early myogenesis appears to be unaffected. We also demonstrate here the existence of a significant myf5 lineage within ribs that has an important role in rib development, suggested by severe rib defects upon ablating the myf5 lineage.
机译：在骨骼肌发育中，成肌调节因子myf5和myoD在成肌细胞的规格和维持中起着多余的作用，而myf6在区分肌细胞和肌纤维方面具有下游作用。尚不清楚myf5和rnyoD之间的冗余是在同一细胞谱系内还是在不同谱系之间。在小鼠中使用谱系追踪和条件性细胞消融，我们证明了在肌发生中存在两个不同的谱系：一个myf5谱系和一个不依赖myf5的谱系。消除myf5谱系与由不依赖myf5的表达myoD的成肌细胞维持的肌发生相容，而消除myf6谱系会导致所有分化的肌纤维缺失，尽管早期肌生成似乎不受影响。我们还在此处证明了肋骨内存在重要的myf5谱系，该谱系在肋骨发育中起着重要作用，这是由于烧蚀myf5谱系时出现严重的肋骨缺损所提示的。

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