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首页> 外文期刊>Developmental cell >Kaiso/p120-catenin and TCF/beta-catenin complexes coordinately regulate canonical Wnt gene targets
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Kaiso/p120-catenin and TCF/beta-catenin complexes coordinately regulate canonical Wnt gene targets

机译：Kaiso / p120-catenin和TCF / beta-catenin复合物可协调调控经典Wnt基因靶标

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beta-catenin-dependent or canonical Writ signals are fundamental in animal development and tumor progression. Using Xenopus laevis, we report that the BTB/POZ zinc finger family member Kalso directly represses canonical Writ gene targets (Siamois, c-Fos, Cyclin-D1, and c-Myc) in conjunction with TCF/LEF (TCF). Analogous to P-catenin relief of TCF repressive activity, we show that p120-catenin relieves Kaiso-mediated repression of Siamois. Furthermore, Kalso and TCF coassociate, and combined Kaiso and TCF derepression results in pronounced Siamois expression and increased beta-catenin coprecipitation with the Siamois promoter. The functional interdependency is underlined by Kalso suppression of P-catenin-induced axis duplication and by TCF-3 rescue of Kalso depletion phenotypes. These studies point to convergence of parallel p120-catenin/Kaiso and beta-catenin/TCF signaling pathways to regulate gene expression in vertebrate development and possibly carcinogenesis.
机译：β-catenin依赖性或规范的Writ信号在动物发育和肿瘤进展中至关重要。我们使用Xenopus laevis报告BTB / POZ锌指家族成员K也与TCF / LEF（TCF）一起直接抑制规范Writ基因靶标（Siamois，c-Fos，Cyclin-D1和c-Myc）。类似于P-catenin减轻TCF抑制活性，我们显示p120-catenin减轻了Kaiso介导的Siamois抑制。此外，Kalso和TCF联合在一起，并结合Kaiso和TCF的阻遏作用，导致Siamois表达明显，并增加了与Siamois启动子的β-catenin共沉淀。通过Kalso抑制P-catenin诱导的轴重复以及通过TCF-3拯救Kalso耗竭表型来强调功能的相互依赖性。这些研究指出，平行的p120-catenin / Kaiso和β-catenin/ TCF信号传导途径的融合将调节脊椎动物发育和可能的癌变过程中的基因表达。

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