Automated actuation of nasal spray products: effect of hand-related variability on the in vitro performance of Flonase nasal spray

Doughty Diane V.; Hsu Wenchi; Dalby Richard N.

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Automated actuation of nasal spray products: effect of hand-related variability on the in vitro performance of Flonase nasal spray

机译：自动启动鼻喷雾剂产品：手相关变异性对Flonase鼻喷雾剂体外性能的影响

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摘要

Objective: To determine if patient-related variability for adults and children recorded during hand spraying of Flonase with an instrumented nasal spray results in significant differences in spray weight, droplet size or spray pattern.

机译：目的：确定在用仪器化的鼻喷雾剂手动喷洒Flonase期间记录的成人和儿童患者相关的变异性是否导致喷雾重量，液滴大小或喷雾方式有显着差异。

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《Drug development and industrial pharmacy》 |2014年第6期|共8页
作者
Doughty Diane V.; Hsu Wenchi; Dalby Richard N.;
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正文语种 eng
中图分类药学;
关键词
Automated actuator; droplet size; force; nasal spray; spray pattern; velocity;

机译：自动执行器;液滴大小;作用力;鼻喷雾;喷雾模式;速度;

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专利

1. Automated actuation of nasal spray products: effect of hand-related variability on the in vitro performance of Flonase nasal spray [J] . Doughty Diane V., Hsu Wenchi, Dalby Richard N. Drug development and industrial pharmacy . 2014,第1a6期

机译：自动启动鼻喷雾剂产品：手相关变异性对Flonase鼻喷雾剂体外性能的影响
2. The influence of actuation parameters on in vitro testing of nasal spray products. [J] . Guo C, Doub WH Journal of pharmaceutical sciences. . 2006,第9期

机译：驱动参数对鼻喷雾产品体外测试的影响。
3. Propagation of uncertainty in nasal spray in vitro performance models using Monte Carlo simulation: Part II. Error propagation during product performance modeling. [J] . Guo C, Doub WH, Kauffman JF Journal of pharmaceutical sciences. . 2010,第8期

机译：使用蒙特卡洛模拟的鼻喷雾剂体外性能模型中不确定性的传播：第二部分。产品性能建模期间的错误传播。
4. Experimental and numerical study of nasal spray characteristics and its application in a realistic human nasal cavity [C] . Xuwen TONG, Jingliang DONG, Kiao INTHAVONG, Australasian Fluid Mechanics Society;Australasian fluid mechanics conference . 2016

机译：鼻喷雾特性的实验和数值研究及其在真实人鼻腔中的应用
5. Evaluation of a device modification and hand-related variability on the performance of nasal sprays and metered dose inhalers. [D] . Doughty, Diane Veronica. 2010

机译：对鼻喷雾剂和定量吸入器的性能进行设备修改和手相关变化的评估。
6. Treatment of Allergic Rhinitis with Ectoine Containing Nasal Spray and Eye Drops in Comparison with Azelastine Containing Nasal Spray and Eye Drops or with Cromoglycic Acid Containing Nasal Spray [O] . Nina Werkhäuser, Andreas Bilstein, Uwe Sonnemann 2014

机译：与含氮司他汀鼻腔喷雾剂和滴眼剂或含cromoglycic acid鼻腔喷雾剂相比含鼻喷剂和依他汀的治疗过敏性鼻炎
7. A Randomized Comparison of the Pharmacokinetics and Bioavailability of Fluticasone Propionate Delivered via Xhance Exhalation Delivery System Versus Flonase Nasal Spray and Flovent HFA Inhalational Aerosol [O] . John C. Messina, Elliot Offman, Jennifer L. Carothers, 2019

机译：通过Xhance呼气输送系统输送的氟替卡松丙酸酯的药代动力学和生物利用度随机比较鼻腔喷雾和短暂的HFA吸入气溶胶

Automated actuation of nasal spray products: effect of hand-related variability on the in vitro performance of Flonase nasal spray

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