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首页> 外文期刊>Journal of Animal Physiology and Animal Nutrition >Maternal low-protein diet affects bone mass and mineral metabolism in suckling rats.
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Maternal low-protein diet affects bone mass and mineral metabolism in suckling rats.

机译：母体低蛋白饮食会影响乳鼠的骨量和矿物质代谢。

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摘要

This study was performed to analyse the effects of low-protein diet (7%) on bone mass and mineral metabolism in rat pups whose mothers were submitted to protein-restricted diet during late pregnancy and early post-natal periods. For this purpose, 12 pregnant Wistar rats were divided into two groups of six animals each: a control group with free access to standard diet (20% protein) and protein-restricted group (PR) fed with low-protein diet (7% protein) from the 14th day of pregnancy until day 14 after delivery. Body weight, femur bone mass, plasma thyroid hormones (FT(4) and FT(3)), biochemical bone marker levels [alkaline phosphatase (ALP), tartrate-resistant acid phosphatase (ACP)] and bone DNA content were recorded. In undernourished pups, a decrease in body weight (-47%, p 0.001) in skeletal growth (-11%, p 0.001) and in bone DNA content (-48%, p 0.001) were observed. Plasma protein and albumin levels and thyroid status were also decreased in undernourished rat pups compared with those of control group. The circulating amino acid levels were decreased in pups. While in their mothers, some of them were increased and the others were decreased. A positive correlation was observed between bone mass and plasma thyroid hormone levels and ALP activity and plasma protein levels, and a negative correlation with ACP activity. Plasma ALP levels were decreased by 19%, whereas plasma tartrate-resistant ACP levels were increased by 33% indicating a hyperactivity of bone remodelling. These results showed that protein-restricted diet given to mothers during late pregnancy and early post-natal periods induced changes in body weight, skeletal growth and bone metabolism in their offspring.
机译：这项研究的目的是分析低蛋白饮食（7％）对幼鼠的骨量和矿物质代谢的影响，这些幼仔的母亲在怀孕后期和产后早期都接受蛋白质限制饮食。为此目的，将12只Wistar怀胎大鼠分为两组，每组六只动物：对照组，可以自由进食标准饮食（20％蛋白质），而蛋白质限制组（PR）则以低蛋白质饮食（7％蛋白质）喂养），从怀孕的第14天到分娩后的第14天。记录体重，股骨骨量，血浆甲状腺激素（FT（4）和FT（3）），生化骨标志物水平[碱性磷酸酶（ALP），抗酒石酸酸性磷酸酶（ACP）]和骨骼DNA含量。在营养不良的幼崽中，骨骼生长（-11％，p <0.001）和骨骼DNA含量（-48％，p <0.001）减少了体重（-47％，p <0.001）。营养不良的幼犬的血浆蛋白和白蛋白水平以及甲状腺状态也较对照组降低。幼犬中循环氨基酸水平降低。在母亲中，有些增加了，有些减少了。骨质量与血浆甲状腺激素水平，ALP活性和血浆蛋白水平之间呈正相关，与ACP活性呈负相关。血浆ALP水平降低了19％，而抗酒石酸盐的ACP水平提高了33％，表明骨骼重塑过度活跃。这些结果表明，在怀孕后期和产后早期，限制蛋白质饮食的母亲会导致其后代的体重，骨骼生长和骨代谢发生变化。

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