TGF beta and matrix-regulated epithelial to mesenchymal transition

Moustakas Aristidis; Heldin Paraskevi

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TGF beta and matrix-regulated epithelial to mesenchymal transition

机译：TGFβ和基质调节的上皮向间质转化

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Background: The progression of cancer through stages that guide a benign hyperplastic epithelial tissue towards a fully malignant and metastatic carcinoma, is driven by genetic and microenvironmental factors that remodel the tissue architecture. The concept of epithelial-mesenchymal transition (EMT) has evolved to emphasize the importance of plastic changes in tissue architecture, and the cross-communication of tumor cells with various cells in the stroma and with specific molecules in the extracellular matrix (ECM).

机译：背景：癌症的发展过程是由良性增生上皮组织向完全恶性和转移性癌发展的阶段，这是由遗传和微环境因素驱动的，这些因素重塑了组织结构。上皮-间质转化（EMT）的概念已经演变为强调组织结构可塑性改变以及肿瘤细胞与基质中各种细胞以及细胞外基质（ECM）中特定分子的交叉通讯的重要性。

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《Biochimica et Biophysica Acta. General Subjects》 |2014年第8期|共14页
作者
Moustakas Aristidis; Heldin Paraskevi;
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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
Epithelial-mesenchymal transition; Hyaluronan; Proteoglycan; Signal transduction; Transforming growth factor beta; Tumor invasiveness;

机译：上皮-间质转化;透明质酸;蛋白聚糖;信号转导;转化生长因子β;肿瘤侵袭性;
入库时间 2022-08-18 09:01:40

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1. TGF beta and matrix-regulated epithelial to mesenchymal transition [J] . Moustakas Aristidis, Heldin Paraskevi Biochimica et Biophysica Acta. General Subjects . 2014,第8期

机译：TGFβ和基质调节的上皮向间质转化
2. EW‐7203, a novel small molecule inhibitor of transforming growth factor‐β (TGF‐β) type I receptor/activin receptor‐like kinase‐5, blocks TGF‐β1‐mediated epithelial‐to‐mesenchymal transition in mammary epithelial cells [J] . Chul-Yong Park, Dae-Kee Kim Cancer science. . 2011,第10期

机译：EW-7203是一种新型的转化生长因子-β（TGF-β）I型受体/激活素受体样激酶-5的新型小分子抑制剂，可阻断TGF-β1介导的乳腺上皮细胞的上皮-间质转化
3. Hispolon as an inhibitor of TGF-beta-induced epithelial-mesenchymal transition in human epithelial cancer cells by co-regulation of TGF-beta-Snail/Twist axis [J] . Hong Darong, Park Min-Ju, Jang Eun Hyang, Oncology letters . 2017,第4aPta2期

机译：Hisogolon作为TGF-Beta-蜗牛/扭曲轴的共调节，作为人上皮癌细胞中TGF-Beta诱导的TGF-Beta诱导的上皮 - 间充质转变的抑制剂
4. Effect of Flavonoid Quercetin on Reversal of TGF-Beta-Induced Epithelial to Mesenchymal Transition in Prostate Cancer (PC-3) CellLine [C] . Meghna Baruah, Neeti Shartna, An P. Khwekar International Molecular Medicine Tri-Conference. . 2016

机译：类黄酮槲皮素对前列腺癌（PC-3）细胞线中TGF-β诱导的TGF-Beta诱导的下皮逆转的影响
5. The identification of TGF-beta signaling pathways that regulate endocardial cell epithelial-to-mesenchymal transformation. [D] . Townsend, Todd Andrew. 2008

机译：调节心内膜细胞上皮到间充质转化的TGF-β信号通路的鉴定。
6. Nox4 involvement in TGF-beta and SMAD3-driven induction of the epithelial-to-mesenchymal transition and migration of breast epithelial cells [O] . Howard E. Boudreau, Benjamin W. Casterline, Balazs Rada, -1

机译：NOx4参与TGF-β和SMAD3驱动的诱导上皮 - 间充质转换和乳房上皮细胞的迁移
7. TGFβ and matrix-regulated epithelial to mesenchymal transition [O] . Moustakas Aristidis, Heldin Paraskevi 2014

机译：TGFβ和基质调节的上皮向间质转化

TGF beta and matrix-regulated epithelial to mesenchymal transition

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