Synthesis and biological evaluation of novel (L)-alpha-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents.

Tandon VK; Yadav DB; Singh RV; Chaturvedi AK; Shukla PK

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Synthesis and biological evaluation of novel (L)-alpha-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents.

机译：新型（L）-α-氨基酸甲酯，杂烷基和芳基取代的1,4-萘醌衍生物作为抗真菌剂和抗菌剂的合成及生物学评估。

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A series of (S)-N-(1,4-naphthoquinon-2-yl)-alpha-amino acid methyl esters 3-9, 2-N,N-dialkylamino-1,4-naphthoquinones 10-11 and 2-hydroxy-3-(2'-mercaptoimidazolyl)-1,4-naphthoquinones and their cyclic analogs 12-15 were synthesized and evaluated for antifungal and antibacterial activities. The structure-activity relationships of these compounds were studied and the results show that the compounds 9b and 13c exhibited in vitro antifungal activity against Candida albicans, Cryptococcus neoformans, and Sporothrix schenckii, whereas compound 6a showed in vitro antibacterial activity against Streptococcus faecalis, K. pneumoniae, Escherichia coli, and Staphylococcus aureus.

机译：一系列（S）-N-（1,4-萘醌-2-基）-α-氨基酸甲酯3-9，2-N，N-二烷基氨基-1,4-萘醌10-11和2-合成了羟基-3-（2'-巯基咪唑基）-1,4-萘醌及其环状类似物12-15，并评估了其抗真菌和抗菌活性。研究了这些化合物的结构活性关系，结果表明化合物9b和13c对白色念珠菌，新隐球菌和schenothrix schenckii表现出体外抗真菌活性，而化合物6a对粪便链球菌K表现出体外抗菌活性。肺炎，大肠埃希菌和金黄色葡萄球菌。

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来源
《Bioorganic and Medicinal Chemistry Letters》 |2005年第23期|共5页
作者
Tandon VK; Yadav DB; Singh RV; Chaturvedi AK; Shukla PK;
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正文语种 eng
中图分类基础医学;
关键词
1; 4-naphthoquinone; Esters; Amino Acids; Synthesis; 酯类; 氨基酸类;

机译：1;4-naphthoquinone;Esters;Amino Acids;Synthesis;酯类;氨基酸类;

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1. Synthesis and biological evaluation of novel (L)-alpha-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents. [J] . Tandon VK, Yadav DB, Singh RV, Bioorganic and Medicinal Chemistry Letters . 2005,第23期

机译：新型（L）-α-氨基酸甲酯，杂烷基和芳基取代的1,4-萘醌衍生物作为抗真菌剂和抗菌剂的合成及生物学评估。
2. Naphtho(2,3-b)(1,4)-thiazine-5,10-diones and 3-substituted-1,4-dioxo-1,4-dihydronaphthalen-2-yl-thioalkanoate derivatives: synthesis and biological evaluation as potential antibacterial and antifungal agents. [J] . Tandon VK, Maurya HK, Yadav DB, Bioorganic and Medicinal Chemistry Letters . 2006,第22期

机译：萘并（2,3-b）（1,4）-噻嗪-5,10-二酮和3-取代的1,4-二氧代-1,4-二氢萘-2-基-硫代链烷酸酯衍生物：合成和生物学评价为潜在的抗菌和抗真菌剂。
3. Synthesis and biological evaluation of novel nitrogen- and sulfur-containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents. [J] . Ibis C, Tuyun AF, Ozsoy Gunes Z, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2011,第12期

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机译：通过用硫酸作为催化剂的2-甲基萘的催化氧化制备2-甲基-1,4-萘醌（维生素K_3）
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机译：2-N-双-（苯甲酰基）氨基-1,4-萘醌，2-芳基萘[2,3-d]恶唑-4,9-二酮和2-芳基-4-苯基亚氨基萘[2，]的合成及生物评价3-d]恶唑-9-类似物作为前列腺癌的潜在化学疗法。
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7. Antifungal Agents. 11. N-Substituted Derivatives of 1-(Aryl)(4-aryl-1H-pyrrol-3-yl) methyl-1H-imidazole: Synthesis, Anti-Candida Activity, and QSAR Studies [O] . -1

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8. Synthesis of Some N-Carboxy Methyl Amino Acid Esters and an Attempt to Prepare Di-(N-Carboxy Methyl Amino Acids Esters)-Sulphones for Possible Antimicrobial Activity [R] . Pasha, T. 1989

机译：一些N-羧甲基氨基酸酯的合成和尝试制备二 - （N-羧甲基氨基酸酯） - 可能的抗菌活性的手机

Synthesis and biological evaluation of novel (L)-alpha-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents.

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