Action mechanism of 6, 6 '-dihydroxythiobinupharidine from Nuphar japonicum, which showed anti-MRSA and anti-VRE activities

Okamura Shinya; Nishiyama Eri; Yamazaki Tomohiro; Otsuka Nao; Taniguchi Shoko; Ogawa Wakano; Hatano Tsutomu; Tsuchiya Tomofusa; Kuroda Teruo

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Action mechanism of 6, 6 '-dihydroxythiobinupharidine from Nuphar japonicum, which showed anti-MRSA and anti-VRE activities

机译：Nuphar japonicum中6，6'-dihydroxythiobinupharidine的作用机制显示抗MRSA和抗VRE活性

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Background: Multidrug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin resistant enterococci (VRE), cause serious infections at clinical sites, for which the development of new drugs is necessary. We screened candidates for new antibiotics and investigated its action mechanism.

机译：背景：耐多药细菌，例如耐甲氧西林的金黄色葡萄球菌（MRSA）和耐万古霉素的肠球菌（VRE），会在临床部位引起严重的感染，因此有必要开发新药。我们筛选了候选抗生素，并研究了其作用机理。

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《Biochimica et Biophysica Acta. General Subjects》 |2015年第6期|共8页
作者
Okamura Shinya; Nishiyama Eri; Yamazaki Tomohiro; Otsuka Nao; Taniguchi Shoko; Ogawa Wakano; Hatano Tsutomu; Tsuchiya Tomofusa; Kuroda Teruo;
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正文语种 eng
中图分类生物化学;
关键词
MRSA; VRE; Nuphar japonicum; DNA topoisomerase IV;

机译：MRSA;VRE;日本睡莲;DNA拓扑异构酶IV;
入库时间 2022-08-18 09:01:41

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1. Action mechanism of 6, 6 '-dihydroxythiobinupharidine from Nuphar japonicum, which showed anti-MRSA and anti-VRE activities [J] . Okamura Shinya, Nishiyama Eri, Yamazaki Tomohiro, Biochimica et Biophysica Acta. General Subjects . 2015,第6期

机译：Nuphar japonicum中6，6'-dihydroxythiobinupharidine的作用机制显示抗MRSA和抗VRE活性
2. Anti-MRSA and Anti-VRE Activity of Compounds Extracted from Marine Streptomyces sp. VITBRK3 [J] . M.R. Benita, K. Kannabiran Journal of Pure & Applied Microbiology . 2014,第6期

机译：从海洋链霉菌中提取的化合物的抗MRSA和抗VRE活性。 VITBRK3
3. Synthesis, Anti-MRSA, and Anti-VRE Activity of Hemin Conjugates with Amino Acids and Branched Peptides [J] . Sergei A. Okorochenkov, Galina A. Zheltukhina, Elena P. Mirchink, Chemical biology and drug design . 2013,第4期

机译：氨基酸和支链肽的血红素结合物的合成，抗MRSA和抗VRE活性
4. Two Putative Holm-Like Peptide with Anti-MRSA Activity and Their Potential Application [C] . Ratchaneewan Aunpad, Siriporn Kaewklom, Watanalai Panbangred American Peptide Symposium . 2013

机译：具有抗MRSA活性的两种推定的Holm样肽及其潜在应用
5. Reconstitution of Coronary Vasculature by an Active Fraction of Geum Japonicum in Ischemic Rat Hearts and the Underlying Mechanisms. [D] . Chen, Hao. 2010

机译：锦葵有效成分在缺血大鼠心脏中重建冠状血管的作用及其潜在机制。
6. Nuphar lutea Extracts Exhibit Anti-Viral Activity against the Measles Virus [O] . Hila Winer, Janet Ozer, Yonat Shemer, 2020

机译：Nuphar lutea提取物表现出对麻疹病毒的抗病毒活性
7. 6,6′-Dihydroxythiobinupharidine (DTBN) Purified from Nuphar lutea Leaves Is an Inhibitor of Protein Kinase C Catalytic Activity [O] . Kamran Waidha, Nikhil Ponnoor Anto, Divya Ram Jayaram, 2021

机译：从Nuphar Lutea叶中纯化的6,6'-二羟基苯丙胺（DTBN）是蛋白激酶C催化活性的抑制剂
8. Part Ⅰ. Development of New Criteria of Reaction Mechanisms The Mechanism of the Tert-Alcohol-Olefin InterconversionnPart Ⅱ. Entropies of Reaction Transition StatesnPart Ⅲ. Salt Effects of Aqueous Electrolytes on The Activity Coefficient of t-Butyl Chloride and its Solvolysis Transition State [R] . Robert W. Tsft 1960

机译：第一部分。反应机理新标准的发展 - 叔醇 - 烯烃互变反应机理Ⅱ。反应过渡态的熵。第三部分。电解质水溶液对叔丁基氯活度系数的盐效应及其溶剂转变态

Action mechanism of 6, 6 '-dihydroxythiobinupharidine from Nuphar japonicum, which showed anti-MRSA and anti-VRE activities

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