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首页> 外文期刊>Journal of Bioinformatics and Computational Biology >DUPLICATED RNA GENES IN TELEOST FISH GENOMES
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DUPLICATED RNA GENES IN TELEOST FISH GENOMES

机译:远亲鱼类基因组中的重复RNA基因

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摘要

Teleost fishes share a duplication of their entire genomes. We report here on a computational survey of structured non-coding RNAs (ncRNAs) in teleost genomes, focusing on the fate of fish-specific duplicates As in other metazoan groups, we find evidence of a large number (11,543) of structured RNAs, most of which (~86%) are clade-specific or evolve so fast that their tetrapod homologs cannot be detected In surprising contrast to protein-coding genes, the fish-specific genome duplication did not lead to a large number of paialogous ncRNAs: only 188 candidates, mostly rnicroRNAs, appear in a larger copy number in teleosts than in tetrapods, suggesting that large-scale gene duplications do not play a major role in the expansion of the veitebrate ncRNA inventory.
机译:硬骨鱼类共享其整个基因组的重复。我们在这里报告了硬骨基因组中的结构化非编码RNA(ncRNA)的计算调查,重点关注鱼类特异复制品的命运与其他后生动物群体一样,我们发现大量(11,543)结构化RNA的证据,其中(〜86%)是进化枝特异性的或进化得如此之快以至于无法检测到它们的四足动物同源物与蛋白质编码基因形成令人惊讶的对比,鱼类特异性基因组重复并没有导致大量的成年ncRNA:只有188种候选物,主要是rnicroRNAs,在硬骨鱼中比在四足动物中以更大的拷贝数出现,这表明大规模的基因复制在veitebrate ncRNA清单的扩大中不发挥主要作用。

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