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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Effect of electrical polarization and composition of biphasic calcium phosphates on early stage osteoblast interactions.
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Effect of electrical polarization and composition of biphasic calcium phosphates on early stage osteoblast interactions.

机译：电极化和两相磷酸钙组成对早期成骨细胞相互作用的影响。

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In spite of having excellent biocompatibility and osteogenic property of hydroxyapatite (HAp) and beta-tricalcium phosphate (beta-TCP), concerns have been raised regarding their degradation kinetics. Complete in vivo degradation of HAp takes years because of its slow degradation rate, and fast degradation rate of beta-TCP limits its application. Biphasic calcium phosphates (BCPs) composed of both HAp and beta-TCP have controlled degradation to some extent. Here, we have prepared three different BCPs composed of beta-TCP and HAp. These BCP composites are successfully electrically polarized to generate surfaces with positive (P-poled) and negative (N-poled) charges. Thermally stimulated depolarized current measurement (TSDC) exhibits increased stored charge density with the increase in HAp percentage in the composites. Our study focuses on understanding the effect of composition variation as well as electrical polarization of these composites on early stage osteoblast-cell adhesion, proliferation, and extracellular matrix (ECM) formation capability. No matter what the composition is, N-poled (Negatively poled) surfaces show early stage osteoblast-cell adhesion, proliferation, and ECM formation when compared with U-poled (unpoled) and P-poled (positively poled) surfaces. Irrespective of the surface charge, an improved cell-material interactions are observed as the percentage of HAp content in the composites is increased. These electrically polarized BCP composites can have potential use in the area of orthopedics and dentistry.
机译：尽管羟基磷灰石（HAp）和β-磷酸三钙（β-TCP）具有出色的生物相容性和成骨性，但人们对其降解动力学提出了关注。 HAp在体内的完全降解需要数年时间，因为它的降解速度慢，而β-TCP的快速降解速度限制了它的应用。由HAp和β-TCP组成的双相磷酸钙（BCP）在一定程度上控制了降解。在这里，我们准备了由beta-TCP和HAp组成的三种不同的BCP。这些BCP复合材料已成功地电极化，以产生带正电荷（P极）和负电荷（N极）的表面。随着复合材料中HAp百分比的增加，热激励去极化电流测量（TSDC）显示出增加的存储电荷密度。我们的研究重点在于了解这些复合材料的成分变化以及极化对早期成骨细胞粘附，增殖和细胞外基质（ECM）形成能力的影响。无论组成是什么，与U极（未极化）和P极（正极化）表面相比，N极（负极化）表面都显示出早期成骨细胞粘附，增殖和ECM形成。不管表面电荷如何，随着复合物中HAp含量的百分比增加，可​​以观察到改善的细胞-材料相互作用。这些电极化的BCP复合材料在整形外科和牙科领域具有潜在用途。

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