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首页> 外文期刊>Journal of biomedical nanotechnology >Assembly and Simple Demonstration of a Micropump Installing PDMS-Based Thin Membranes as Flexible Micro Check Valves
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Assembly and Simple Demonstration of a Micropump Installing PDMS-Based Thin Membranes as Flexible Micro Check Valves

机译：微型泵的组装和简单演示，该微型泵将基于PDMS的薄膜安装为柔性微型止回阀

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Integration of chemical or biochemical systems creates extremely efficient devices exploiting theadvantages of microspaces. Recently, various microfluidic devices have been developed to makemicro chemical processes more sophisticated. On the other hand, we demonstrated the concept ofa cardiomyocyte pump using only chemical energy input to cells as a driver (Tanaka et al. Lab Chip6(3), pp. 362-368). However, its flow rate was too poor to be applied for practical applications ofmicro chemical systems mainly because of the inefficiency of the check valves made of polyimide.As cardiomyocytes' force is weak, more flexible materials must be used. In this report, a moreflexible material, poly(dimethylsiloxane) (PDMS) check valves were designed and fabricated, andthen, the check valve function was demonstrated by pumping fluid in an assembled micropumpincorporating the PDMS check valves. Water was dropped on an inlet of the microchannel, and adiaphragm of the micropump was oscillated using a pair of tweezers to prove the function of thevalves. From the result, pumping volume per stroke was calculated as 1.7 μL/stroke. The developedvalves are not only usable for our cardiomyocyte pumps but also applicable to general micro andnano fluidic devices for biomedical fields such as immune assay systems owning to easy andinexpensive fabrication method of the valves.
机译：化学或生化系统的集成利用微空间的优势创建了极其高效的设备。近来，已经开发了各种微流体装置以使微化学过程更复杂。另一方面，我们证明了心肌细胞泵的概念仅使用输入到细胞的化学能作为驱动因子（Tanaka等人，Lab Chip6（3），第362-368页）。但是，由于聚酰亚胺制止回阀效率低下，因此其流速太差而不能用于微化学系统的实际应用。由于心肌细胞的作用力较弱，因此必须使用更柔软的材料。在本报告中，设计并制造了一种更具挠性的材料聚二甲基硅氧烷（PDMS）止回阀，然后通过将流体泵入组装了PDMS止回阀的微型泵中来演示止回阀的功能。将水滴到微通道的入口上，并用一对镊子振荡微泵的隔膜，以证明阀的功能。根据结果​​，每冲程的泵送量计算为1.7μL/冲程。所开发的阀门不仅可用于我们的心肌泵，而且还适用于生物医学领域的通用微型和纳米流体装置，例如具有简便且廉价的阀门制造方法的免疫分析系统。

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