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首页> 外文期刊>Journal of child neurology >Clinical and Electroencephalographic (EEG) Features Associated With Refractoriness in Benign Childhood Epilepsy With Centrotemporal Spikes
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Clinical and Electroencephalographic (EEG) Features Associated With Refractoriness in Benign Childhood Epilepsy With Centrotemporal Spikes

机译：临床和脑电图（EEG）的特征与良性儿童癫痫伴中央颞尖刺的难治性相关

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摘要

The aim of this study is to identify clinical or electroencephalographic (EEG) features associated with refractoriness to the initial antiepileptic drug in typical benign childhood epilepsy with centrotemporal spikes. A total of 87 children with typical benign childhood epilepsy with centrotemporal spikes were retrospectively reviewed in the analyses. The patients were subdivided into 2 groups: patients whose seizures were controlled with monotherapy and patients requiring 2 medications. Sixty-three children achieved seizure freedom with monotherapy, whereas 24 received 2 medications for seizure control. Diffusing foci at the follow-up EEG and delayed treatment (duration >1 year) are 2 main risk factors associated with more refractory cases (P < .001). Delayed diagnosis (37.1%) and nonadherence to treatment (57.2%) contributed to delayed treatment. Our findings suggested that diffusing foci on EEG and delayed treatment are associated with more frequent seizures and refractoriness in benign childhood epilepsy with centrotemporal spikes. Diagnostic delays and nonadherence hindered timely care, which may represent opportunities for improved intervention.
机译：这项研究的目的是确定临床或脑电图（EEG）的特征，该特征与典型的儿童温和性癫痫伴中央颞尖峰的初始抗癫痫药的难治性有关。回顾性分析了总共87例典型的儿童良性癫痫发作，颞叶中央尖峰的儿童。将患者分为两组：通过单一疗法控制癫痫发作的患者和需要2种药物治疗的患者。六十三名儿童通过单一疗法实现了癫痫发作的自由，而24名儿童接受了两种药物来控制癫痫发作。随访脑电图弥漫性病灶和延迟治疗（持续时间> 1年）是与更多难治病例相关的两个主要危险因素（P <.001）。延迟诊断（37.1％）和不坚持治疗（57.2％）导致延迟治疗。我们的研究结果表明，在儿童期良性癫痫伴中央颞尖峰时，脑电图扩散灶和延迟治疗与癫痫发作和难治性发作更为频繁有关。诊断延迟和不依从性阻碍了及时护理，这可能代表了改善干预措施的机会。

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