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首页> 外文期刊>Journal of child psychology and psychiatry >Regulatory variant of the TPH2 gene and early life stress are associated with heightened attention to social signals of fear in infants
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Regulatory variant of the TPH2 gene and early life stress are associated with heightened attention to social signals of fear in infants

机译：TPH2基因的调节变异和早期生活压力与婴儿对恐惧社会信号的高度关注有关

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Background Cross-species evidence suggests that genetic and experiential factors act early in development to establish individual emotional traits, but little is known about the mechanisms that emerge during this period to mediate long-term outcomes. Here, we tested the hypothesis that known genetic and environmental risk conditions may heighten infants' natural tendency to attend to threat-alerting stimuli, resulting in a cognitive bias that may contribute to emotional vulnerability. Methods Data from two samples of 5-7-month-old infants (N = 139) were used to examine whether established candidate variations in the serotonin-system genes, i.e., TPH2 SNP rs4570625 (-703 G/T) and HTR1A SNP rs6295 (-1019 G/C), and early rearing condition (maternal stress and depressive symptoms) are associated with alterations in infants' attention to facial expressions. Infants were tested with a paradigm that assesses the ability to disengage attention from a centrally presented stimulus (a nonface control stimulus or a neutral, happy, or fearful facial expression) toward the location of a new stimulus in the visual periphery (a geometric shape). Results TPH2 -703 T-carrier genotype (i.e., TT homozygotes and heterozygotes), presence of maternal stress and depressive symptoms, and a combination of the T-carrier genotype and maternal depressive symptoms were associated with a relatively greater difficulty disengaging attention from fearful facial expressions. No associations were found with infants' temperamental traits. Conclusions Alterations in infants' natural attentional bias toward fearful facial expressions may emerge prior to the manifestation of emotional and social behaviors and provide a sensitive marker of early emotional development.
机译：背景跨物种的证据表明，遗传和经验因素在发育的早期就起作用以建立个体的情绪特征，但对这一时期出现的介导长期结果的机制知之甚少。在这里，我们检验了一种假设，即已知的遗传和环境风险条件可能会提高婴儿参加威胁改变刺激的自然倾向，从而导致可能导致情绪脆弱性的认知偏见。方法使用来自两个5-7个月大婴儿（N = 139）的数据来检查血清素系统基因（即TPH2 SNP rs4570625（-703 G / T）和HTR1A SNP rs6295）中是否建立了候选变异。 （-1019 G / C）和早期抚养条件（母亲的压力和抑郁症状）与婴儿对面部表情的注意力变化有关。对婴儿进行了范式测试，该范式评估了将注意力从集中呈现的刺激（非面部控制刺激或中性，快乐或恐惧的面部表情）转移到视觉周围新刺激的位置（几何形状）的能力。结果TPH2 -703 T携带者基因型（即TT纯合子和杂合子），母体压力和抑郁症状的存在以及T携带者基因型和母体抑郁症状的组合与将注意力从恐惧的面部中解脱出来的难度相对较大。表达式。没有发现与婴儿的气质特征相关。结论婴儿对恐惧面部表情的自然注意力偏见的改变可能在情绪和社交行为出现之前出现，并提供了早期情绪发展的敏感标志。

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