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首页> 外文期刊>Journal of Comparative Pathology >Outbreak of Tuberculosis in a Colony of Rhesus Monkeys (Macaca mulatta) after Possible Indirect Contact with a Human TB Patient
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Outbreak of Tuberculosis in a Colony of Rhesus Monkeys (Macaca mulatta) after Possible Indirect Contact with a Human TB Patient

机译：与人类结核病患者可能间接接触后，恒河猴群落（猕猴）中的结核病暴发

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Simian tuberculosis is one of the most important bacterial diseases of non-human primates. Outbreaks of tuberculosis have been reported in primate colonies almost as long as these animals have been used experimentally or kept in zoological gardens. Significant progress has been made in reducing the incidence of tuberculosis in captive non-human primates, but despite reasonable precautions, outbreaks continue to occur. The most relevant reason is the high incidence of tuberculosis (TB) amongst the human population, in which tuberculosis is regarded as an important re-emerging disease. Furthermore, many non-human primate species originate from countries with a high burden of human TB. Therefore, Mycobacterium tuberculosis remains a significant threat in animals imported from countries with high rates of human infection. We report an outbreak of tuberculosis among a group of rhesus monkeys (Macaca mulatta) living in a closed, long-term colony. The outbreak coincided with reactivation of a TB infection in a co-worker who never had direct access to the animal house or laboratories. Eleven of 26 rhesus monkeys developed classical chronic active tuberculosis with typical caseous granulomata of varying size within different organs. The main organ system involved was the lung, suggesting an aerosol route of infection. Such an outbreak has significant economic consequences due to animal loss, disruption of research and costs related to disease control. Precautionary measures must be improved in order to avoid TB in non-human primate colonies. (C) 2015 Elsevier Ltd. All rights reserved.
机译：猿猴结核是非人类灵长类动物最重要的细菌性疾病之一。几乎在灵长类动物群落中就已报告了结核病暴发，只要这些动物已被实验性使用或饲养在动物园中。在减少圈养非人类灵长类动物的结核病发病率方面已取得重大进展，但是尽管采取了适当的预防措施，但暴发仍在继续。最相关的原因是人群中结核病（TB）的发病率高，其中结核病被视为一种重要的再发疾病。此外，许多非人类灵长类物种起源于人类结核病负担高的国家。因此，结核分枝杆菌仍然是从人类感染率高的国家进口的动物的重大威胁。我们报告了一群居住在封闭的长期殖民地的恒河猴（猕猴）的结核病暴发。暴发发生在从未直接接触动物舍或实验室的同事中，结核病感染重新发作。 26只恒河猴中有11只发展成典型的慢性活动性肺结核，并在不同器官内出现大小不一的典型干酪肉芽肿。涉及的主要器官系统是肺部，表明存在气溶胶感染途径。由于动物损失，研究中断和与疾病控制有关的费用，这种暴发具有重大的经济后果。必须改进预防措施，以免在非人类灵长类动物群落中出现结核病。 （C）2015 Elsevier Ltd.保留所有权利。

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