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首页> 外文期刊>Journal of clinical neuroscience: official journal of the Neurosurgical Society of Australasia >Assessment of sleep satisfaction in patients with dementia due to Alzheimer's disease
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Assessment of sleep satisfaction in patients with dementia due to Alzheimer's disease

机译：阿尔茨海默氏病痴呆患者的睡眠满意度评估

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摘要

Sleep length and architecture are potential markers of progressive cognitive impairment, while neuropsychiatric symptoms and APOE4- haplotypes have been associated with more sleep complaints in patients with dementia due to Alzheimer's disease (AD). In this cross-sectional study, we sought to investigate which factors might be related to sleep satisfaction in patients with AD. A total of 217 consecutive patients with AD were assessed for demographic features, neuropsychiatric symptoms, cognitive decline, functional impairment for activities of daily living, caregiver burden, APOE haplotypes, self-reported sleep satisfaction and length of sleep. Statistical comparisons were conducted with significance at p < 0.05. Concerning sleep complaints, 179 patients (82.5%) reported satisfactory sleep, while 38 (17.5%) were Unsatisfied, with no relation to age, sex, APOE haplotypes, obesity, education, marital status, alcohol consumption or smoking found. Length of sleep (p = 0.011) and behavioural symptoms (p = 0.009) had significant associations with sleep satisfaction. Length of sleep was positively correlated with apathy (p = 0.014) and scores on the Clock Drawing Test (p = 0.015), and inversely correlated with anxiety (p = 0.015) and independence for instrumental activities of daily living (p = 0.003). Patients who were treated with memantine (p = 0.02) or anti-psychotics (p < 0.01) had longer duration of sleep. In conclusion, behavioural symptoms had strong associations with sleep satisfaction, which is highly correlated with length of sleep in patients with AD. Functional independence, apathy, anxiety, use of memantine or anti-psychotics, and scores on the Clock Drawing Test were significantly associated with length of sleep in this sample. (C) 2014 Elsevier Ltd. All rights reserved.
机译：睡眠时间和体格结构是进行性认知障碍的潜在标志，而神经精神症状和APOE4-单倍型已与阿尔茨海默氏病（AD）引起的痴呆患者的更多睡眠障碍相关。在这项横断面研究中，我们试图研究哪些因素可能与AD患者的睡眠满意度有关。总共对217名连续的AD患者进行了人口统计学特征，神经精神症状，认知能力下降，日常生活活动的功能障碍，护理人员负担，APOE单倍型，自我报告的睡眠满意度和睡眠时间的评估。进行统计学比较，其显着性为p <0.05。关于睡眠方面的投诉，有179位患者（82.5％）报告的睡眠良好，而38位（17.5％）的患者不满意，与年龄，性别，APOE单倍型，肥胖，教育程度，婚姻状况，饮酒或吸烟无关。睡眠时间（p = 0.011）和行为症状（p = 0.009）与睡眠满意度显着相关。睡眠时间与冷漠（p = 0.014）和时钟绘图测试得分（p = 0.015）呈正相关，与焦虑（p = 0.015）和日常生活工具活动的独立性（p = 0.003）呈负相关。美金刚（p = 0.02）或抗精神病药（p <0.01）的患者的睡眠时间更长。总之，行为症状与睡眠满意度密切相关，这与AD患者的睡眠时间高度相关。功能独立性，冷漠，焦虑，美金刚或抗精神病药的使用以及时钟绘图测试的分数与该样本的睡眠时间显着相关。 （C）2014 Elsevier Ltd.保留所有权利。

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