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首页> 外文期刊>Journal of chromatography, A: Including electrophoresis and other separation methods >Detection of chemical warfare agent degradation products in foods using liquid chromatography coupled to inductively coupled plasma mass spectrometry and electrospray ionization mass spectrometry
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Detection of chemical warfare agent degradation products in foods using liquid chromatography coupled to inductively coupled plasma mass spectrometry and electrospray ionization mass spectrometry

机译：液相色谱-电感耦合等离子体质谱法和电喷雾电离质谱法检测食品中的化学战剂降解产物

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The following work presents the exploration of three chromatographic separations in combination with inductively coupled plasma mass spectrometry (ICP-MS) for the analysis of chemical warfare agent degradation products (CWADPs). The robust ionization of ICP is virtually matrix independent thus enabling the examination of sample matrices generally considered too complicated for analysis by electrospray ionization (ESI) or atmospheric pressure chemical ionization MS with little to no sample preparation. The analysis was focused on detecting CWADPs in food matrices, as they present possible vehicles for terrorist contamination. Due to the specific detection of P-31 by ICP-MS, resolution of analytes of interest from other P-containing interferences (H3PO4) was a crucial part of each separation. Up to 10 CWADPs were separated in the presence of H3PO4 with detection limits in the low part per billion levels using the methods described. Additionally, one method was tailored to be compatible with both ICP-MS and ESI-MS making structural verification possible. (C) 2008 Elsevier B.V. All rights reserved.
机译：以下工作结合化学耦合剂降解产物（CWADPs）的电感耦合等离子体质谱（ICP-MS）提出了三种色谱分离方法的探索。 ICP的强大电离实际上是与基质无关的，因此可以检查样品基质，而通常认为这些样品基质对于通过电喷雾电离（ESI）或大气压化学电离MS进行分析而言过于复杂，几乎不需要样品制备。该分析着重于检测食品基质中的CWADP，因为它们提供了可能造成恐怖分子污染的工具。由于通过ICP-MS对P-31进行了特异性检测，因此从其他含P的干扰物（H3PO4）中分离出目标分析物是每次分离的关键部分。使用所述方法，在H3PO4存在下最多分离出10个CWADP，检测限在十亿分之几的低水平。此外，量身定制的一种方法可与ICP-MS和ESI-MS兼容，从而使结构验证成为可能。 （C）2008 Elsevier B.V.保留所有权利。

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