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首页> 外文期刊>Journal of Crohn’s & colitis >Clinical status, psychosocial impairments, medical treatment and health care costs for patients with inflammatory bowel disease (IBD) in Germany: An online IBD registry
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Clinical status, psychosocial impairments, medical treatment and health care costs for patients with inflammatory bowel disease (IBD) in Germany: An online IBD registry

机译：德国炎症性肠病（IBD）患者的临床状况，心理社会障碍，医疗和保健费用：在线IBD注册中心

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Background: The aim of this cross-sectional study was to establish an online inflammatory bowel disease (IBD) registry for a first picture of the situation of IBD outpatients' treatment in Germany. Methods: Between March 2006 and July 2007 IBD outpatients from 24 gastroenterological specialist practices and two hospitals in Germany were enrolled in an Internet-based registry to evaluate the outpatients' clinical status, psychological impairments, provided health care, as well as medical treatment and medication costs. Results: 1032 IBD patients (ulcerative colitis/UC: 519; Crohn's disease/CD: 511; indeterminate colitis: 2) were enrolled in the study (age: 43 ± 14. years/M ± SD). Disease duration of all patients averaged 10 ± 8.5. years. In 519 UC-patients (49% male; 33% pancolitis), 66% were in remission as were 55% of CD patients (37 % male; 41 % active smokers). Associated with higher rates of disease activity (CDAI ≥ 150; CAI > 4) were corticosteroids (CD, UC), topical medication (UC), relevant reported depressive symptoms (15%; 6-31%) and impairments in sexuality (21%; 9-42%). Relevant medication groups prescribed were oral aminosalicylates (UC: 70%; CD: 47%); immunosuppressive therapy - mostly azathioprine/6 MP (CD: 47%; UC: 26%), and Infliximab (CD: 8%; UC: 3%).Strongly associated with their clinical disease activity in UC as well as CD patients, 15% (6-31%) reported relevant depressive symptoms and 21% (9-42%) relevant impairments in sexuality. Conclusions: The registry constitutes a large complemental database for the patient population in Germany. About one third of the IBD patients were not in clinical remission (CDAI ≥ 150/CAI > 4) (CD: 45%; UC: 27%), although high rates of immunosuppressive drugs (CD: 47%; UC 26%) were administered. This study shows a large burden of active disease associated with an unexpectedly high (co)morbidity and high psychosocial impairments, indicating a reduced health state in IBD patients.
机译：背景：这项横断面研究的目的是建立在线炎症性肠病（IBD）注册中心，以初步了解德国IBD门诊病人的治疗情况。方法：在2006年3月至2007年7月之间，对来自德国24家肠胃病专科诊所和两家医院的IBD门诊患者进行了互联网注册，以评估门诊患者的临床状况，心理障碍，提供医疗保健以及药物治疗和药物治疗费用。结果：该研究纳入了1032名IBD患者（溃疡性结肠炎/ UC：519;克罗恩病/ CD：511;不确定性结肠炎：2）（年龄：43±14岁/ M / SD）。所有患者的病程平均为10±8.5。年份。在519名UC患者中（49％男性; 33％胰腺炎），缓解率66％，CD患者的55％（37％男性; 41％吸烟者）缓解。与较高的疾病活动率（CDAI≥150; CAI> 4）相关的是糖皮质激素（CD，UC），局部用药（UC），相关的报道的抑郁症状（15％; 6-31％）和性障碍（21％ ; 9-42％）。处方的相关药物组为口服氨基水杨酸盐​​（UC：70％; CD：47％）;免疫抑制疗法-多数为硫唑嘌呤/ 6 MP（CD：47％; UC：26％）和Infliximab（CD：8％; UC：3％），这与他们在UC和CD患者中的临床疾病活动密切相关15 ％（6-31％）报告相关的抑郁症状，而21％（9-42％）报告相关的性障碍。结论：该注册表构成了德国患者人群的大型补充数据库。尽管免疫抑制药物的发生率很高（CD：47％; UC 26％），但约有三分之一的IBD患者未达到临床缓解（CDAI≥150 / CAI> 4）（CD：45％; UC：27％）。管理。这项研究显示，活动性疾病负担重，与意外的高（合并）发病率和高的社会心理障碍相关，表明IBD患者的健康状况降低。

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