Evolution of anti-HIV drug candidates. Part 1: From alpha-Anilinophenylacetamide (alpha-APA) to imidoyl thiourea (ITU).

Ludovici DW; Kukla MJ; Grous PG; Krishnan S; Andries K; de-Bethune M; Azijn H; Pauwels R; De-Clercq E; Arnold E; Janssen PA

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Evolution of anti-HIV drug candidates. Part 1: From alpha-Anilinophenylacetamide (alpha-APA) to imidoyl thiourea (ITU).

机译：抗艾滋病毒候选药物的演变。第1部分：从α-苯胺基苯乙酰胺（α-APA）到亚胺基硫脲（ITU）。

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Stemming from work on a previous clinical candidate, loviride, and other alpha-APA derivatives, a new series of potent non-nucleoside reverse transcriptase inhibitors (NNRTIs) has been synthesized. The ITU analogues, which contain a unique diarylated imidoyl thiourea, are very active in inhibiting both wild-type and clinically important mutant strains of HIV-1.

机译：从以前的临床候选药物洛韦洛德和其他α-APA衍生物的研究工作出发，已经合成了一系列新的有效的非核苷逆转录酶抑制剂（NNRTIs）。包含独特的二芳基亚氨基酰亚胺基硫脲的ITU类似物在抑制HIV-1的野生型和临床上重要的突变株方面都非常有效。

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《Bioorganic and Medicinal Chemistry Letters》 |2001年第17期|共4页
作者
Ludovici DW; Kukla MJ; Grous PG; Krishnan S; Andries K; de-Bethune M; Azijn H; Pauwels R; De-Clercq E; Arnold E; Janssen PA;
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正文语种 eng
中图分类药学;生物化学;
关键词
Alpha; APA; Thiourea; Intensive Care Units; 硫脲; 加强医疗病房;

机译：Alpha;APA;Thiourea;Intensive Care Units;硫脲;加强医疗病房;

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1. Evolution of anti-HIV drug candidates. Part 1: From alpha-Anilinophenylacetamide (alpha-APA) to imidoyl thiourea (ITU). [J] . Ludovici DW, Kukla MJ, Grous PG, Bioorganic and Medicinal Chemistry Letters . 2001,第17期

机译：抗艾滋病毒候选药物的演变。第1部分：从α-苯胺基苯乙酰胺（α-APA）到亚胺基硫脲（ITU）。
2. Prediction of anti-HIV activity of imidoyl thioureas: QSAR approach [J] . Veerasamy Ravichandran, Vishnukanth Mourya, Ram Kishore Agrawal Medicinal Chemistry Research . 2009,第8期

机译：酰亚胺基硫脲的抗HIV活性预测：QSAR方法
3. Prediction of anti-HIV activity of imidoyl thioureas:QSAR approach [J] . Veerasamy Ravichandran, Vishnukanth Mourya, Ram Kishore Agrawal Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents . 2009,第8期

机译：酰亚胺基硫脲抗HIV活性的预测：QSAR方法
4. MALDI-MS quantitative analysis of organometallic complexes: application to anti-cancer drug candidates. [C] . Cecile Perret, Helene Nierengarten, Christian Gaiddon, International Mass Spectrometry Conference . 2014

机译：有机金属配合物的Maldi-MS定量分析：抗癌药物候选者的应用。
5. Mechanistic Models of Anti-HIV Microbicide Drug Delivery. [D] . Gao, Yajing. 2016

机译：抗HIV杀菌剂药物传递的机理模型。
6. Synthesis and Anti-HIV Activity of New Metabolically Stable Alkenyldiarylmethane (ADAM) Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) Incorporating N-Methoxy Imidoyl Halide and 124-Oxadiazole Systems [O] . Takeshi Sakamoto, Matthew D. Cullen, Tracy L. Hartman, -1

机译：新型代谢稳定的亚烷基二芳基甲烷（ADAM）非核苷逆转录酶抑制剂（NNRTIs）的合成和抗HIV活性结合了N-甲氧基亚氨基卤化物和124-Oxadiazole系统
7. Synthesis and anti-HIV activity of new metabolically stable alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors incorporating N-methoxy imidoyl halide and 1,2,4-oxadiazole systems [O] . Sakamoto, Takeshi, Cullen, Matthew D, Hartman, Tracy L, 2007

机译：新的代谢稳定的烯基二芳基甲烷非核苷逆转录酶抑制剂的合成及其抗HIV活性，结合了N-甲氧基亚氨基卤化物和1,2,4-恶二唑系统

Evolution of anti-HIV drug candidates. Part 1: From alpha-Anilinophenylacetamide (alpha-APA) to imidoyl thiourea (ITU).

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