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首页> 外文期刊>Journal of hepato-biliary-pancreatic surgery >Intrahepatic cholangiocarcinoma: macroscopic type and stage classification.
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Intrahepatic cholangiocarcinoma: macroscopic type and stage classification.

机译：肝内胆管癌：宏观类型和分期。

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The Liver Cancer Study Group of Japan established a classification of macroscopic type and the TNM staging of intrahepatic cholangiocarcinoma (ICC). With the observation of more than 240 resected cases of ICC, three fundamental types were established. They were: (1) mass-forming (MF) type, (2) periductal-infiltrating (PI) type, and (3) intraductal growth (IG) type. The MF type forms a definite mass, located in the liver parenchyma. The PI type is defined as ICC which extends mainly longitudinally along the bile duct, often resulting in dilatation of the peripheral bile duct. The IG type proliferates toward the lumen of the bile duct papillarily or like a tumor thrombus. The TNM classification of ICC was then designed, using 136 cases of the MF type resected curatively between 1990 and 1996 at member institutes. Univariate and multivariate analyses showed: (1) tumor 2 cm or less, (2) single nodule, and (3) no vascular and serous membrane invasion as prognostic factors. T factors were defined as follows:T1 is an ICC that meets all requirements of factors (1), (2), and (3); T2 meets two of the three requirements, T3 meets one of the three requirements and T4 meets none of the three requirements. Our data did not support the idea that the hepatoduodenal lymph node is regional. The N factors were defined as N0 no lymph node metastasis; and N1, positive at any nodes. Thus, the stages of ICC were defined as stage I, T1N0M0; stage II, T2N0M0; stage III, T3N0M0; stage IVA, T4N0M0 or any TN1M0; and stage IVB, any T any NM1.
机译：日本肝癌研究小组建立了肝内胆管癌（ICC）的宏观类型和TNM分期的分类。通过观察超过240例ICC切除病例，建立了三种基本类型。它们是：（1）质量形成（MF）型，（2）导管周围浸润（PI）型和（3）导管内生长（IG）型。 MF型形成一定质量，位于肝实质内。 PI型定义为ICC，其主要沿胆管纵向延伸，通常导致周围胆管扩张。 IG型向乳头状或类似肿瘤血栓的方向扩散到胆管腔。然后设计了ICC的TNM分类，使用了1990年至1996年间在会员机构治愈的136例MF型病例。单因素和多因素分析显示：（1）肿瘤小于或等于2厘米，（2）单结节，（3）无血管和浆膜浸润作为预后因素。 T因子定义如下：T1是满足因子（1），（2）和（3）的所有要求的ICC; T2满足三个需求中的两个，T3满足三个需求中的一个，而T4不满足三个需求中的一个。我们的数据不支持肝十二指肠淋巴结是区域性的。 N个因素定义为N0无淋巴结转移; N1，在任何节点为正。因此，ICC的阶段定义为阶段I，T1N0M0;第二阶段，T2N0M0;第三阶段，T3N0M0; IVA，T4N0M0或任何TN1M0级; IVB期，任何T到NM1。

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