Design, synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antifungal and anticancer agents.

Tandon VK; Chhor RB; Singh RV; Rai S; Yadav DB

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Design, synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antifungal and anticancer agents.

机译：设计，合成和评估新型1，4-萘醌衍生物作为抗真菌剂和抗癌剂。

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A series of 1,4-naphthoquinone derivatives were synthesized and tested for antifungal and antitumor activity against a number of fungal disease causative species and Walker 256 carcinoma cell lines. The results show that the compounds 8a,e and 11b possess pronounced antifungal profile where as 7b and f were found to be active against Walker 256 carcinoma cell lines. Moreover 7c and 11a showed inhibitory effect against reverse transcriptase enzyme from Rauscher Murine Leukemia Virus.

机译：合成了一系列的1,4-萘醌衍生物，并测试了其对多种真菌病原性物种和Walker 256癌细胞系的抗真菌和抗肿瘤活性。结果表明，化合物8a，e和11b具有明显的抗真菌特性，其中发现7b和f对Walker 256癌细胞系具有活性。此外，7c和11a对Rauscher鼠白血病病毒的逆转录酶具有抑制作用。

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《Bioorganic and Medicinal Chemistry Letters》 |2004年第5期|共5页
作者
Tandon VK; Chhor RB; Singh RV; Rai S; Yadav DB;
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原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
derivatives; 1; 4-naphthoquinone; novel; Evaluation;

机译：衍生物;1;4-萘醌;新颖;评价;

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1. Design, synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antifungal and anticancer agents. [J] . Tandon VK, Chhor RB, Singh RV, Bioorganic and Medicinal Chemistry Letters . 2004,第5期

机译：设计，合成和评估新型1，4-萘醌衍生物作为抗真菌剂和抗癌剂。
2. Synthesis and biological evaluation of novel (L)-alpha-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents. [J] . Tandon VK, Yadav DB, Singh RV, Bioorganic and Medicinal Chemistry Letters . 2005,第23期

机译：新型（L）-α-氨基酸甲酯，杂烷基和芳基取代的1,4-萘醌衍生物作为抗真菌剂和抗菌剂的合成及生物学评估。
3. Design, synthesis and biological evaluation of novel nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents. [J] . Tandon VK, Maurya HK, Mishra NN, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2009,第8期

机译：设计，合成和生物学评估新型含氮和硫的杂1,4-萘醌类作为有效的抗真菌和抗菌剂。
4. Utilization of Cinnamaldehyde for Synthesis of Nitrogencontaining 2-Hydroxy-1,4-Naphthoquinone Derivatives as Antioxidant Agent [C] . N. Nurhikmah, A. H. Cahyana, A. R. Liandi International Symposium on Current Progress in Mathematics and Sciences . 2020

机译：用利用肉桂醛的合成硝基因特突出的2-羟基-1,4-萘醌衍生物作为抗氧化剂
5. Synthesis, structure-activity relationship study, and mode of action study of 1,4-naphthoquinone based anticancer and antimicrobial agents. [D] . Shrestha, Jaya P. 2016

机译：1,4-萘醌类抗癌剂和抗菌剂的合成，构效关系研究和作用方式研究。
6. Design synthesis and anticancer activity of naphthoquinone derivatives [O] . Xiao-bao Shen, Yang Wang, Xuan-zhen Han, 2020

机译：萘醌衍生物的设计合成及抗癌活性
7. Synthesis, Characterization, Antibacterial, and Antifungal Activities of Cobalt(II), Nickel(II) and Copper(II) Complexes with 3-thioacetyl-2-amino-1,4-naphthoquinone and 2-benzoyl-3-amino-1,4-naphthoquinone Ligands [O] . Fatma S. M. Hassan, Mahmoud Fayez, Nadia Abdalla 2020

机译：用3-硫代乙酰-2-氨基-1,4-萘醌和2-苯甲酰-3-氨基-1，钴（II），镍（II），镍（II）和铜（II）配合物的合成，表征，抗菌和抗真菌活性， 4-萘醌配体

Design, synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antifungal and anticancer agents.

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