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首页> 外文期刊>Journal of mass spectrometry: JMS >Rapid and facile detection of four date rape drugs in different beverages utilizing proton transfer reaction mass spectrometry (PTR-MS)
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Rapid and facile detection of four date rape drugs in different beverages utilizing proton transfer reaction mass spectrometry (PTR-MS)

机译：利用质子转移反应质谱（PTR-MS）快速简便地检测不同饮料中的四种枣油菜药物

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摘要

In this work, we illustrate the application of proton transfer reaction mass spectrometry (PTR-MS) in the field of food and drink safety. We present proof-of-principle measurements of four different drinks (water, tea, red wine and white wine) each spiked separately with four different date rape drugs (chloral hydrate, tricholorethanol, γ-butyrolactone and butanediol). At first, the ideal PTR-MS operating conditions (reduced electric field strength and monitoring the most abundant [fragment] ion) for detection of the drugs were determined utilizing a time-of-flight-based PTR-MS instrument. We then dissolved small quantities of the drugs (below the activation threshold for effects on humans) into the various types of drinks and detected them using a quadrupole-based PTR-MS instrument via two different sampling methods: (1) dynamic headspace sampling and (2) direct liquid injection. Both methods have their advantages and drawbacks. Only with dynamic headspace sampling can rape drug contaminations be detected within a timeframe of seconds, and therefore, this method is the most promising use of PTR-MS as a fast, sensitive and selective monitor for the detection of food and drink contamination.
机译：在这项工作中，我们说明了质子转移反应质谱法（PTR-MS）在食品和饮料安全领域中的应用。我们提供了四种不同饮料（水，茶，红酒和白葡萄酒）的原理验证测量结果，每种饮料分别掺有四种不同日期的强奸药（水合氯醛，三氯乙醇，γ-丁内酯和丁二醇）。首先，使用基于飞行时间的PTR-MS仪器确定用于检测药物的理想PTR-MS操作条件（降低的电场强度并监测最丰富的[碎片]离子）。然后，我们将少量药物（低于对人的影响的激活阈值以下）溶解到各种类型的饮料中，并使用基于四极杆的PTR-MS仪器通过两种不同的采样方法进行检测：（1）动态顶空采样和（ 2）直接注液。两种方法都有其优点和缺点。只有通过动态顶空采样，才能在几秒钟的时间内检测出强奸药物污染，因此，该方法是PTR-MS最有希望的用途，它是一种用于检测食品和饮料污染的快速，灵敏和选择性的监测器。

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