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首页> 外文期刊>Journal of Materials Chemistry, B. materials for biology and medicine >Modified chitosan coated mesoporous strontium hydroxyapatite nanorods as drug carriers
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Modified chitosan coated mesoporous strontium hydroxyapatite nanorods as drug carriers

机译：改性壳聚糖包覆的介孔羟基磷灰石纳米棒作为药物载体

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Mesoporous strontium hydroxyapatite (SrHAp) nanorods (NRs) have been successfully synthesized using a simple and efficient chemical route, i.e. the hydrothermal method. Structural and morphological characterization of the as-synthesized SrHAp NRs have been performed by transmission electron microscopy (TEM) and high angle annular dark field scanning transmission electron microscopy (HAADF-STEM). TEM and HAADF-STEM measurements of the NRs reveal the coexistence of longer and shorter particles with the length ranging from 50 nm to 400 nm and a diameter of about 20-40 nm. Electron tomography measurements of the NRs allow us to better visualize the mesopores and their facets. Two model drugs, hydrophobic risperidone and hydrophilic pramipexole, were loaded into the SrHAp NRs. These nanorods were coated using a modified chitosan (CS) with poly(2-hydroxyethyl methacrylate) (PHEMA), in order to encapsulate the drug-loaded SrHAp nanoparticles and reduce the cytotoxicity of the loaded materials. The drug release from neat and encapsulated SrHAp NRs mainly depends on the drug hydrophilicity. Importantly, although neat SrHAp nanorods exhibit some cytotoxicity against Caco-2 cells, the Cs-g-PHEMA-SrHAp drug-loaded nanorods show an acceptable cytocompatibility.
机译：介孔羟磷灰石锶（SrHAp）纳米棒（NRs）已通过简单有效的化学途径（即水热法）成功合成。合成的SrHAp NRs的结构和形态表征已经通过透射电子显微镜（TEM）和高角度环形暗场扫描透射电子显微镜（HAADF-STEM）进行了表征。 NR的TEM和HAADF-STEM测量表明，更长和更短的颗粒共存，其长度范围为50 nm至400 nm，直径约为20-40 nm。 NR的电子断层扫描测量使我们能够更好地可视化中孔及其小平面。将两种模型药物疏水性利培酮和亲水性普拉克索装入SrHAp NRs中。这些纳米棒使用改性的脱乙酰壳多糖（CS）和聚（甲基丙烯酸2-羟乙酯）（PHEMA）进行包覆，以包裹载药的SrHAp纳米颗粒并降低载药材料的细胞毒性。从纯净和封装的SrHAp NRs中释放的药物主要取决于药物的亲水性。重要的是，尽管纯净的SrHAp纳米棒对Caco-2细胞表现出一定的细胞毒性，但载有Cs-g-PHEMA-SrHAp的纳米棒却显示出可接受的细胞相容性。

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