Induction of human IgM and IgG anti-GM1 antibodies in transgenic mice in response to lipopolysaccharides from Campylobacter jejuni.

Latov N

首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Induction of human IgM and IgG anti-GM1 antibodies in transgenic mice in response to lipopolysaccharides from Campylobacter jejuni.

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Induction of human IgM and IgG anti-GM1 antibodies in transgenic mice in response to lipopolysaccharides from Campylobacter jejuni.

机译：响应来自空肠弯曲杆菌的脂多糖，在转基因小鼠中诱导人IgM和IgG抗GM1抗体。

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Campylobacter jejuni lipopolysaccharides (LPS) are implicated in the development of autoantibodies to GM1 ganglioside in patients with neuropathy following C. jejuni infection. CjLPS bears oligosaccharides that are cross reactive with GM1 ganglioside and presumably exerts its effects via molecular mimicry. To study the mechanisms that are involved in development of the autoantibody response, a transgenic mouse line was developed that expresses an IgM anti-GM1 antibody derived from a patient with multifocal motor neuropathy (MMN). In vivo stimulation of the transgenic mice with C. jejuni lipopolysaccharides (CjLPS), but not of wild-type mice readily elicited high serum titers of anti-GM1 IgM antibodies, followed by IgG anti-GM1 antibodies after two booster injections. In in vitro experiments, CjLPS stimulated the transgenic B-cells at lower concentration than control LPS. The increased sensitivity to CjLPS and the induction of IgG anti-GM1 by CjLPS but not control LPS are consistent with a mechanism of B-cell activation that involves both the LPS and the antigen-specific surface Ig receptors, with possible participation of T-cells.

机译：空肠弯曲杆菌脂多糖（LPS）与空肠弯曲杆菌感染后神经病患者的GM1神经节苷脂自身抗体有关。 CjLPS带有与GM1神经节苷脂交叉反应的寡糖，大概是通过分子模拟发挥其作用。为了研究涉及自身抗体反应发展的机制，开发了一种转基因小鼠品系，该品系表达源自患有多灶性运动神经病（MMN）的患者的IgM抗GM1抗体。用空肠弯曲杆菌脂多糖（CjLPS）体内刺激转基因小鼠，而不是野生型小鼠体内刺激，容易引起高滴度的抗GM1 IgM抗体血清，然后在两次加强注射后诱发IgG抗GM1抗体。在体外实验中，CjLPS以低于对照LPS的浓度刺激转基因B细胞。对CjLPS的敏感性增加以及CjLPS诱导IgG抗GM1而不是对照LPS的诱导与B细胞活化的机制一致，该机制涉及LPS和抗原特异性表面Ig受体，并可能参与T细胞。

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《Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology》 |2004年第2期|共13页
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Latov N;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Laboratory mice; Antibodies; Immunoglobulin G measurement; Immunoglobulin M measurement; 抗体; 脂多糖类;

机译：Laboratory mice;Antibodies;Immunoglobulin G measurement;Immunoglobulin M measurement;抗体;脂多糖类;

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1. Induction of human IgM and IgG anti-GM1 antibodies in transgenic mice in response to lipopolysaccharides from Campylobacter jejuni. [J] . Latov N Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2004,第1a2期

机译：响应来自空肠弯曲杆菌的脂多糖，在转基因小鼠中诱导人IgM和IgG抗GM1抗体。
2. Reactivity of serum IgG anti-GM1 ganglioside antibodies with the lipopolysaccharide fractions of Campylobacter jejuni isolates from patients with Guillain-Barre syndrome (GBS). [J] . Gregson NA, Rees JH, Hughes RA Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 1997,第1a2期

机译：血清IgG抗GM1神经节苷脂抗体与吉兰-巴雷综合征（GBS）患者空肠弯曲菌分离株的脂多糖组分的反应性。
3. Protection against Brucella melitensis or Brucella abortus in mice with immunoglobulin G (IgG), IgA, and IgM monoclonal antibodies specific for a common epitope shared by the Brucella A and M smooth lipopolysaccharides. [J] . A Cloeckaert, I Jacques, P de Wergifosse, Infection and immunity . 1992,第1期

机译：具有免疫球蛋白G（IgG），IgA和IgM单克隆抗体的小鼠针对布鲁氏菌或流产布鲁氏菌的保护，这些抗体对布鲁氏菌A和M平滑脂多糖共有的常见表位具有特异性。
4. Deglycosylation Study of Murine IgG1, IgG2a, IgG2b, and Humanized IgG1 Monoclonal Antibodies [C] . Megan Ellis, John Lambert, Alexandru C. Lazar American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：鼠IgG1，IgG2a，IgG2b和人源化IgG1单克隆抗体的脱糖基化研究
5. Induction of myosin cross-reactive antibody and cytolytic T cell responses in mice with Streptococcus pyogenes. [D] . Cunningham, Cynthia Ann. 2000

机译：化脓性链球菌小鼠中肌球蛋白交叉反应抗体的诱导和溶细胞性T细胞反应。
6. Guillain-Barré Syndrome- and Miller Fisher Syndrome-Associated Campylobacter jejuni Lipopolysaccharides Induce Anti-GM1 and Anti-GQ1b Antibodies in Rabbits [O] . C. W. Ang, M. A. De Klerk, H. P. Endtz, 2001

机译：Guillain-Barré综合征和Miller Fisher综合征相关的空肠弯曲杆菌脂多糖诱导兔抗GM1和抗GQ1b抗体
7. Guillain-Barré syndrome- and Miller Fisher syndrome-associated Campylobacter jejuni lipopolysaccharides induce anti-GM1 and anti-GQ1b Antibodies in rabbits. [O] . Klerk, M.A. de, Endtz, H.P. (Hubert), Jacobs, B.C. (Bart), 2001

机译：Guillain-Barré综合征和Miller Fisher综合征相关的空肠弯曲杆菌脂多糖诱导兔抗GM1和抗GQ1b抗体。
8. Indirect Immunoglobulin G (IgG) and IgM Enzyme-Linked Immunosorbent Assays (ELISAs) and IgM Capture ELISA for Detection of Antibodies to Lipopolysaccharide in Adult Typhoid Fever Patients in Pakistan. [R] . Sippel, J., Bukhtiari, N., Awan, M. B., 1989

机译：间接免疫球蛋白G（IgG）和Igm酶联免疫吸附试验（ELIsas）和Igm捕获ELIsa检测巴基斯坦成年伤寒患者脂多糖抗体。

Induction of human IgM and IgG anti-GM1 antibodies in transgenic mice in response to lipopolysaccharides from Campylobacter jejuni.

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