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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Systemic auto-antibodies in children with autism
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Systemic auto-antibodies in children with autism

机译：自闭症儿童的全身性自身抗体

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Autoimmunity to central nervous system may have a role in the pathogenesis of autism. A subset of anti-ds-DNA antibodies has been recently proved to be pathogenic to the brain as well as to the kidney. Due to the paucity of studies investigating the frequency of systemic auto-antibodies in autism, we are the first to investigate the frequency of anti-ds-DNA antibodies in a group of autistic children. The seropositivity of anti-nuclear antibodies (ANA) was also investigated. Serum anti-ds-DNA antibodies and ANA were measured in 100 autistic children, aged between 4 and 11. years, in comparison to 100 healthy-matched children. The seropositivity of anti-ds-DNA antibodies and ANA in autistic children was 34% and 25%, respectively. In addition, 42% of autistic children were seropositive for anti-ds-DNA antibodies and/or ANA. The frequencies of anti-ds-DNA antibodies and ANA in autistic children were significantly higher than that in healthy children (4% and 2%, respectively), (P. <. 0.001 and P. <. 0.001, respectively). Autistic children with a family history of autoimmunity (45%) had significantly higher frequency of serum anti-ds-DNA antibodies (48.9%) than patients without such a history (21.8%), P. = 0.008. There was a significant positive association between the seropositivity of anti-ds-DNA antibodies and ANA (P. <. 0.001). In conclusion, anti-ds-DNA antibodies and ANA were found in the sera of a subgroup of autistic children. However, replication studies of larger samples are warranted to validate whether these antibodies are a mere association or have a pathogenic role in some autistic children.
机译：对中枢神经系统的自身免疫可能在自闭症的发病机制中起作用。最近已证明抗ds-DNA抗体的子集对大脑和肾脏均具有致病性。由于研究自闭症中系统性自身抗体的频率的研究很少，因此我们是第一个研究一组自闭症儿童中抗ds-DNA抗体频率的方法。还研究了抗核抗体（ANA）的血清阳性。与100名健康匹配的儿童相比，在100名4至11岁的自闭症儿童中测量了血清抗ds-DNA抗体和ANA。自闭症儿童的抗ds-DNA抗体和ANA的血清阳性率分别为34％和25％。另外，有42％的自闭症儿童对抗ds-DNA抗体和/或ANA呈血清阳性。自闭症儿童的抗ds-DNA抗体和ANA的频率显着高于健康儿童（分别为4％和2％）（分别为P. <.0.001和P。<。0.001）。具有自身免疫家族史的自闭症儿童（45％）的血清抗ds-DNA抗体的频率（48.9％）比没有这种病史的患者（21.8％）高，P。= 0.008。抗ds-DNA抗体的血清阳性与ANA之间存在显着的正相关（P. <。0.001）。总之，在自闭症儿童亚群的血清中发现了抗ds-DNA抗体和ANA。但是，必须进行较大样本的复制研究才能验证这些抗体是单纯的关联还是在某些自闭症儿童中具有致病作用。

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