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Serum interleukin-27 expression in patients with myasthenia gravis

机译:重症肌无力患者血清白细胞介素27的表达

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摘要

Myasthenia gravis (MG)(1) is an autoimmune disease directed at the neuromuscular junction, and cytokines are thought to contribute to its immunopathogenesis. Interleukin-27 (IL-27)(2) plays a complex and pleiotropic role in immune responses associated with T helper cells. To assess the role of IL-27 in MG, we determined serum IL-27 levels in MG patients (n = 32) compared to healthy controls (n = 50). The median serum IL-27 level was significantly higher in MG patients (35.947 pg/mL) than in controls (19.885 pg/mL). Furthermore, serum IL-27 was significantly higher in early onset MG. This study suggests the possibility that IL-27 might contribute to MG pathogenesis or immunoregulation. (C) 2015 Elsevier B.V. All rights reserved.
机译:重症肌无力(MG)(1)是一种针对神经肌肉接头的自身免疫性疾病,细胞因子被认为有助于其免疫发病机理。白介素27(IL-27)(2)在与T辅助细胞相关的免疫反应中起着复杂而多效的作用。为了评估IL-27在MG中的作用,我们确定了MG患者(n = 32)与健康对照组(n = 50)相比的血清IL-27水平。 MG患者的平均血清IL-27水平(35.947 pg / mL)显着高于对照组(19.885 pg / mL)。此外,在早期发病的MG中,血清IL-27显着升高。这项研究表明IL-27可能有助于MG发病机理或免疫调节。 (C)2015 Elsevier B.V.保留所有权利。

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