首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >MMP-2-1575 G/A polymorphism modifies the onset of optic neuritis as a first presenting symptom in MS?
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MMP-2-1575 G/A polymorphism modifies the onset of optic neuritis as a first presenting symptom in MS?

机译:MMP-2-1575 G / A基因多态性改变视神经炎的发作是MS的首发症状。

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摘要

Previous studies show altered activities of matrix metalloproteinase (MMP)-2 and MMP-9 in serum and cerebrospinal fluid of multiple sclerosis (MS) and neuromyelitis optica (NMO) patients. Optic neuritis (ON) is a common symptom of both disorders. Here we investigated the impacts of MMP-2 - 1575 G/A and MMP-9 - 1562 C/T gene polymorphisms on disease phenotype in 100 MS patients with ON as a first symptom and 376 MS patients with other initial symptomatology. The MMP-2 - 1575 G/A polymorphism led to a 5-year-earlier age of disease onset in MS patients with ON as a first symptom (p = 0.009). (C) 2015 Elsevier B.V. All rights reserved.
机译:先前的研究表明多发性硬化症(MS)和视神经脊髓炎(NMO)患者的血清和脑脊液中基质金属蛋白酶(MMP)-2和MMP-9的活性发生了改变。视神经炎(ON)是这两种疾病的常见症状。在这里,我们调查了MMP-2-1575 G / A和MMP-9-1562 C / T基因多态性对100例首发症状为ON的MS患者和376例其他初期症状为MS的患者疾病表型的影响。 MMP-2-1575 G / A基因多态性导致MS患者的5年前开始发病,并将其作为第一症状(p = 0.009)。 (C)2015 Elsevier B.V.保留所有权利。

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