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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Polymeric nanospheres as strategy to increase the amount of triclosan retained in the skin: passive diffusion vs. iontophoresis
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Polymeric nanospheres as strategy to increase the amount of triclosan retained in the skin: passive diffusion vs. iontophoresis

机译：聚合物纳米球作为增加皮肤中三氯生残留量的策略：被动扩散与离子电渗疗法

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The aim of this study was to evaluate the passive and iontophoretic permeation of triclosan in human skin using a triclosan solution and tridosan-loaded cationic nanospheres in order to determine which of the two strategies is more effective in allowing the deposition of triclosan within the skin. Tridosan-loaded nanospheres were prepared by the emulsification-solvent displacement technique using aminoalkyl methacry-late (Eudragit~R RL 100) as polymer matrix. Nanospheres of 261.0 ±15.1 nm with a positive surface charge (Ψz = 26.0 ±3.2 mV) were obtained. Drug loading was 62.0 ± 1.7%. Results demonstrated that the amount of triclosan retained within the skin was significantly greater (8.5-fold) when this was encapsulated into cationic nanospheres and administered by passive diffusion than when the triclosan solution was employed. The amount of triclosan retained within the skin when the cationic nanospheres were administered by iontophoresis was 3.1-fold greater than when the triclosan solution was administered by passive diffusion. Iontophoresis proved to be effective in enhancing the passage of triclosan in solution throughout the skin, whereas the triclosan nanospheres could achieve a local effect by forming a controlled release dermal depot.
机译：这项研究的目的是使用三氯生溶液和负载三氯生的阳离子纳米球评估三氯生在人体皮肤中的被动渗透和离子渗透，以确定这两种策略中哪种更有效地使三氯生沉积在皮肤内。以甲基丙烯酸氨基烷基酯（Eudragit〜R RL 100）为聚合物基质，通过乳化-溶剂置换技术制备了负载三多聚糖的纳米球。得到具有正表面电荷（Ψz= 26.0±3.2 mV）的261.0±15.1 nm纳米球。载药量为62.0±1.7％。结果表明，将三氯生包裹在阳离子纳米球中并通过被动扩散给药时，与使用三氯生溶液时相比，保留在皮肤中的数量明显更多（8.5倍）。当通过离子电渗疗法施用阳离子纳米球时，保留在皮肤中的三氯生的量比通过被动扩散施用三氯生溶液时的保留量高3.1倍。离子电渗疗法可有效增强溶液中三氯生在整个皮肤中的通过，而三氯生纳米球可通过形成控释真皮贮库来达到局部作用。

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