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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Spray-dried microparticulate systems containing acetaminophen
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Spray-dried microparticulate systems containing acetaminophen

机译：含对乙酰氨基酚的喷雾干燥微粒系统

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摘要

The present work investigates the preparation and the release of acetaminophen from spray-dried microparticles. Two cellulose derivatives were tested as sustaining agents: microcrystalline cellulose (MCC) and sodium carboxymethylcellulose (NaCMC). In-vitro dissolution studies were carried out in dissolution metida of different pH. With MCC, the adsorption of acetaminophen on the surface or in the surface or in the pores of the polymer does not allow a significant sustained release of the durg, which completely dissolves in 1 h. Conversely, the use of NaCMC retards the release of acetaminophen over a period of 6-8 h. The drug releasedepends on the plasticizer used and on the pH of the dissolution medium, and the mechanism consists essentially in the diffusion of the drug through the swollen polymeric matrix. the pH dependence observed can be correlated with a lower hydrophylicity of the polyemr in acidic medium, which retards gel formation.
机译：本工作研究了对乙酰氨基酚的制备和从喷雾干燥的微粒中的释放。测试了两种纤维素衍生物作为维持剂：微晶纤维素（MCC）和羧甲基纤维素钠（NaCMC）。在不同pH的溶解方法中进行了体外溶解研究。使用MCC，对乙酰氨基酚在聚合物的表面或表面或孔中的吸附不会显着持续释放杜格，杜格在1小时内完全溶解。相反，使用NaCMC可在6-8小时内延迟对乙酰氨基酚的释放。药物释放取决于所用的增塑剂和溶解介质的pH，其机理主要在于药物通过溶胀的聚合物基质的扩散。观察到的pH依赖性可能与Polyemr在酸性介质中的较低亲水性有关，这会延迟凝胶的形成。

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