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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Effect of microfluidization parameters on the physical properties of PEG-PLGA nanoparticles prepared using high pressure microfluidization
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Effect of microfluidization parameters on the physical properties of PEG-PLGA nanoparticles prepared using high pressure microfluidization

机译：微流化参数对高压微流制备PEG-PLGA纳米粒子物理性能的影响

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摘要

The objective of this work was to develop uniformly distributed poly(ethylene glycol) grafted poly(lactide-co-glycolide) (PEG-PLGA) nanoparticles of mean size range ~100-200 nm using ethyl acetate as the solvent. In the multiple emulsion solvent evaporation method a high pressure microfluidization process was adopted to produce the W/O/W multiple emulsion. Non-toxic ethyl acetate was used to solubilize PEG-PLGA. The mean size of nanoparticles obtained was less than 180 nm. The particle size and size distribution were dependent on the microfluidization conditions applied. Mean particle size steadily increased from 121 nm at three passes to 172nm at 20 passes of the microfluidizer, indicating that over-processing may be detrimental to PEG-PLGA nanoparticles prepared using this technique. There was no significant alteration of the PEG-PLGA matrix, as evidenced from the differential scanning calorimetric studies.
机译：这项工作的目的是使用乙酸乙酯作为溶剂，开发平均粒径范围为〜100-200 nm的均匀分布的聚（乙二醇）接枝的聚（丙交酯-乙交酯）（PEG-PLGA）纳米粒子。在多乳液溶剂蒸发法中，采用高压微流化工艺来生产W / O / W多乳液。使用无毒乙酸乙酯溶解PEG-PLGA。获得的纳米颗粒的平均尺寸小于180nm。粒度和粒度分布取决于所应用的微流化条件。微流化器的平均粒径从三遍的121 nm稳定增加到20遍的172 nm，表明过度处理可能不利于使用此技术制备的PEG-PLGA纳米颗粒。如差示扫描量热研究所证明的，PEG-PLGA基质没有明显改变。

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