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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Preparation and characterization of spray dried inhalable powders containing chitosan nanoparticles for pulmonary delivery of isoniazid
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Preparation and characterization of spray dried inhalable powders containing chitosan nanoparticles for pulmonary delivery of isoniazid

机译：含壳聚糖纳米粒子的喷雾干燥可吸入性粉末的制备及表征，用于异烟肼的肺部递送

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摘要

The aim of this study was to prepare spray dried inhalable powders containing isoniazid-loaded chitosan/ tripolyphosphate (TPP) nanoparticles for sustained delivery of the drug to the lung. Nanoparticles were prepared by ionic gelation method. In-vitro drug release study indicated that the rate of drug release from nanoparticles was decreased by increasing the amount of chitosan. Entrapment of isoniazid into chitosan/ TPP nanoparticles decreased minimum inhibitory concentrations (MIC) of the drug against mycobacterium avium intracellulare. Nanoparticles were spray dried using excipients such as lactose, mannitol and malto-dextrin alone or with leucine. Results showed that the obtained powders had different aerosolization property. It was observed that by adding leucine, the particle size of microparticles deceased and the process yield and fine particle fraction (FPF) increased significantly. The in-vitro deposition data indicated that spray drying of isoniazid-loaded nanoparticles with lactose in the presence of leucine resulted in the production of inhalable powders with the highest FPF (45%).
机译：这项研究的目的是制备含有异烟肼负载的壳聚糖/三聚磷酸盐（TPP）纳米颗粒的喷雾干燥可吸入粉末，以将药物持续输送到肺部。通过离子凝胶法制备纳米颗粒。体外药物释放研究表明，通过增加壳聚糖的量可以降低药物从纳米颗粒释放的速率。异烟肼截留在壳聚糖/ TPP纳米颗粒中会降低药物对鸟分枝杆菌胞内菌的最低抑制浓度（MIC）。使用赋形剂如乳糖，甘露醇和麦芽糊精单独或与亮氨酸一起喷雾干燥纳米颗粒。结果表明，所得粉末具有不同的雾化性能。观察到，通过添加亮氨酸，微粒的粒径减小并且工艺产率和细颗粒分数（FPF）显着增加。体外沉积数据表明，在亮氨酸存在下，用乳糖将负载异烟肼的纳米粒子与乳糖进行喷雾干燥可生产出具有最高FPF（45％）的可吸入粉末。

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