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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Alendronate PLGA microspheres with high loading efficiency for dental applications
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Alendronate PLGA microspheres with high loading efficiency for dental applications

机译：具有高负载效率的Alendronate PLGA微球，可用于牙科应用

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Purpose:Alendronate sodium,used systemically as a bone protective agent,proved to also be effective locally in various dental bone applications.Development of alendronate-loaded microspheres with high loading efficiency for such applications would be greatly challenged by the hydrophilicity and low MW of the drug.The aim of this study was to incorporate alendronate sodium,into poly(lactide-co-glycolide)(PLGA)microspheres(MS)with high loading efficiency.Methods:Three multiple emulsion methods:water-in-oil-in-water(W/O/W),water-in-oil-in-oil(W/O1/O2)and solid-in-oil-in-oil(S/O1/O2)were tested.In addition to entrapment efficiency,MS were characterized for surface morphology,particle size,in vitro drug release and in vitro degradation of the polymer matrix.Alendronate microspheres with maximum drug loading and good overall in vitro performance were obtained using the W/O1/O2 emulsion technique.Results:Drug release from the microspheres exhibited a triphasic release pattern over a period of 13 days,the last fast release phase being associated with more rapid degradation of the PLGA matrix.Conclusions:Biocompatible,biodegradable PLGA microspheres incorporating alendronate sodium with high loading efficiency obtained in this study may offer promise as a delivery system for bisphosphonates in dental and probably other clinical applications.
机译：用途：阿仑膦酸钠作为全身性骨保护剂，已被证明在各种牙科骨应用中也局部有效。开发具有高负载效率的负载阿仑膦酸盐的微球将面临亲水性和低MW的巨大挑战。本研究的目的是将阿仑膦酸钠掺入聚丙交酯-乙交酯-乙交酯（PLGA）微球（MS）中，并具有较高的填充效率。方法：三种多重乳液法：水包油包水（W / O / W），油中油包水（W / O1 / O2）和油中固体包油（S / O1 / O2）的测试。除包封效率外，对MS的表面形貌，粒径，体外药物释放和聚合物基质的体外降解进行了表征。使用W / O1 / O2乳液技术获得了具有最大载药量和良好体外性能的阿仑膦酸盐微球。微球的释放在一段时间内表现出三重释放模式13天，最后一个快速释放阶段与PLGA基质的更快降解有关。结论：本研究中获得的具有高负载效率的掺入阿仑膦酸钠的生物相容性，可生物降解的PLGA微球可作为双膦酸盐在牙齿中的传递系统，并可能其他临床应用。

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