• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Nutritional Science and Vitaminology >L-tryptophan suppresses rise in blood glucose and preserves insulin secretion in type-2 diabetes mellitus rats
【24h】

L-tryptophan suppresses rise in blood glucose and preserves insulin secretion in type-2 diabetes mellitus rats

机译：L-色氨酸抑制2型糖尿病大鼠的血糖升高并保持胰岛素分泌

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Ample evidence indicates that a high-protein/low-carbohydrate diet increases glucose energy expenditure and is beneficial in patients with type-2 diabetes mellitus (T2DM). The present study was designed to investigate the effects of L-tryptophan in T2DM. Blood glucose was measured by the glucose dehydrogenase assay and serum insulin was measured with ELISA in both normal and hereditary T2DM rats after oral glucose administration with or without L-D-tryptophan and tryptamine. The effect of tryptophan on glucose absorption was examined in the small intestine of rats using the everted-sac method. Glucose incorporation in adipocytes was assayed with [3H]-2-deoxy-D-glucose using a liquid scintillation counter. Indirect computer-regulated respiratory gas-assay calorimetry was applied to assay energy expenditure in rats. L-Tryptophan suppressed both serum glucose and insulin levels after oral glucose administration and inhibited glucose absorption from the intestine. Tryptamine, but not L-tryptophan, enhanced insulin-stimulated [3H]-glucose incorporation into differentiated adipocytes. L-Tryptophan increased glucose-associated energy expenditure in rats in vivo. L-Tryptophan-rich chow consumed from a young age preserved the secretion of insulin and delayed the progression of T2DM in hereditary diabetic rats. The results suggested that L-tryptophan suppresses the elevation of blood glucose and lessens the burden associated with insulin secretion from β-cells.
机译：大量证据表明，高蛋白/低碳水化合物饮食会增加葡萄糖能量消耗，对2型糖尿病（T2DM）患者有益。本研究旨在研究L-色氨酸在T2DM中的作用。在口服或不服用L-D-色氨酸和色胺的情况下，在正常和遗传性T2DM大鼠中，通过葡萄糖脱氢酶测定法测量血糖，并通过ELISA测定血清胰岛素。色氨酸对大鼠小肠中葡萄糖吸收的影响采用翻囊法进行了研究。使用液体闪烁计数器用[3H] -2-脱氧-D-葡萄糖测定脂肪细胞中的葡萄糖掺入。间接计算机调节呼吸气体测定量热法用于测定大鼠的能量消耗。口服葡萄糖后，L-色氨酸抑制血清葡萄糖和胰岛素水平，并抑制肠道中葡萄糖的吸收。色胺（而非L-色氨酸）可增强胰岛素刺激的[3H]-葡萄糖掺入分化的脂肪细胞中。 L-色氨酸增加了大鼠体内葡萄糖相关的能量消耗。从年轻时开始食用的富含L-色氨酸的食物保留了胰岛素的分泌，并延迟了遗传性糖尿病大鼠中T2DM的发展。结果表明，L-色氨酸可抑制血糖升高，并减轻与β细胞分泌胰岛素有关的负担。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号