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首页> 外文期刊>Journal of Nutritional Science and Vitaminology >Comparative effects of risedronate and calcitriol on cancellous bone in rats with glucocorticoid-induced osteopenia.
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Comparative effects of risedronate and calcitriol on cancellous bone in rats with glucocorticoid-induced osteopenia.

机译：利塞膦酸盐和骨化三醇对糖皮​​质激素诱导的骨质减少大鼠的松质骨的比较作用。

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OBJECTIVES: To compared the effects of risedronate (Ris) and calcitriol (Cal) on cancellous bone in rats with glucocorticoid (GC)-induced osteopenia. MATERIALS AND METHODS: Thirty female Sprague-Dawley rats, 4 mo of age, were randomly divided by the stratified weight method into three groups of 10 rats each according to the following treatment schedule: 8-wk GC administration with 4-wk vehicle (control), Ris, and Cal as therapeutic treatment initiated after 4-wk GC administration. The GC (methylprednisolone sodium succinate, 5.0 mg/kg, s.c.), Ris (10 microg/kg, s.c.), and Cal (0.1 microg/kg. p.o.) were administered 3 times a week. At the end of the 8-wk treatment period, two-dimensional (2D) bone histomorphometric analysis was performed for cancellous bone of the proximal tibial metaphysis, 3D micro-computed tomographic analysis was performed for the distal femoral metaphysis, and the mechanical strength of the distal femoral metaphysis was evaluated by a compression test. RESULTS: Ris and Cal treatment increased both 2D and 3D cancellous bone mass. However, Ris treatment exhibited more pronounced effects on 2D and 3D cancellous bone mass than Cal treatment, and the effects of both Ris and Cal treatment were greater on 3D cancellous bone mass than on 2D cancellous bone mass. The response of 2D and 3D cancellous bone mass to Ris treatment was characterized by its effect on trabecular number and thickness, which was associated with markedly suppressed bone resorption and bone formation in terms of suppressed bone turnover. On the other hand, the response of 2D cancellous bone mass to Cal treatment was attributed to the effect of Cal on 2D trabecular thickness, and the response of 3D cancellous bone mass to Cal treatment might be characterized by the effect of Cal on 3D trabecular number and thickness, with a more marked effect of trabecular thickness. These effects were primarily due to mildly suppressed bone resorption and maintained or even increased bone formation. Despite the differential effect of Ris and Cal treatment on the cancellous bone structure and bone metabolism, both treatment increased the maximum load and braking energy of the distal femoral metaphysis to a similar extent, suggesting different mechanisms for improving bone strength. CONCLUSIONS: This study showed the differential effects of Ris and Cal on cancellous bone in rats with GC-induced osteopenia.
机译：目的：比较利塞膦酸盐（Ris）和骨化三醇（Cal）对糖皮质激素（GC）诱导的骨质减少大鼠的松质骨的影响。材料与方法：30只4月龄的Sprague-Dawley雌性大鼠，按照以下治疗方案，通过分层体重法随机分为3组，每组10只，按以下治疗方案进行：8周GC联合4周载体（对照组） ），Ris和Cal作为4周GC给药后的治疗方法。每周3次给药GC（甲基强的松龙琥珀酸钠5.0 mg / kg，皮下），Ris（10 microg / kg，皮下）和Cal（0.1 microg / kg.p.o。）。在8周治疗期结束时，对胫骨近端干meta端的松质骨进行了二维（2D）骨组织形态分析，对股骨远端干physi端进行了3D显微计算机断层扫描，通过压缩试验评估股骨远端干compression端。结果：Ris和Cal治疗可增加2D和3D松质骨质量。但是，Ris治疗对2D和3D松质骨质量的影响比Cal治疗更显着，Ris和Cal治疗对3D松质骨质量的影响均大于2D松质骨质量。 2D和3D松质骨质量对Ris治疗的反应的特征在于其对骨小梁数量和厚度的影响，这在抑制骨转换方面与明显抑制骨吸收和骨形成有关。另一方面，2D松质骨质量对Cal治疗的反应归因于Cal对2D小梁厚度的影响，而3D松质骨质量对Cal治疗的反应可能是由Cal对3D小梁数目的影响来表征的。和厚度，对小梁厚度的影响更为明显。这些作用主要归因于骨骼吸收的轻度抑制以及骨骼形成的维持甚至增加。尽管Ris和Cal治疗对松质骨结构和骨代谢有不同的影响，但两种治疗均以相似的程度增加了股骨远端干physi端的最大负荷和制动能量，提示了改善骨强度的不同机制。结论：这项研究显示了Ris和Cal对GC诱导的骨质减少的大鼠松质骨的不同作用。

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