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首页> 外文期刊>Journal of neurology >Genetic abnormalities in oligodendroglial and ependymal tumours.
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Genetic abnormalities in oligodendroglial and ependymal tumours.

机译:少突胶质和室间隔瘤的遗传异常。

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摘要

Oligodendroglial and ependymal tumours are not the most common glial neoplasms; however, they are important subtypes of gliomas with different tumour biologies. Cytogenetic information has suggested that losses of chromosomes 1 p and 19 q are the most frequent genetic alterations in oligodendroglial tumours. Combined loss of these chromosomes has been associated with better chemotherapeutic response and prolonged overall survival. Loss of chromosome 22 is a well defined abnormality in ependymomas. In addition, deletion of chromosome 6 q may be another frequent chromosomic aberration in paediatric ependymomas.
机译:少突胶质和室间隔瘤不是最常见的神经胶质瘤。然而,它们是具有不同肿瘤生物学的神经胶质瘤的重要亚型。细胞遗传学信息表明,染色体1 p和19 q的丢失是少突胶质细胞肿瘤中最常见的遗传改变。这些染色体的综合丢失与更好的化学治疗反应和更长的总生存期有关。 22号染色体的丢失是室管膜瘤中定义明确的异常。另外,染色体6q的缺失可能是小儿室管膜瘤的另一种常见的染色体畸变。

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